Correlate Longitudinal Changes in Spirometry with Longitudinal Changes in the CT Scan and CXR in the Diagnosis of Lung Cancer

Principal Investigator

Name
Mark Dransfield

Institution
University of Alabama at Birmingham

Position Title
Associate Professor

Email
mdrans99@uab.edu

About this CDAS Project

Study
NLST (Learn more about this study)

Project ID
2003-90005

Initial CDAS Request Approval
Jun 5, 2003

Title
Correlate Longitudinal Changes in Spirometry with Longitudinal Changes in the CT Scan and CXR in the Diagnosis of Lung Cancer

Summary
Study now called, "Radiographic Predictors of Pulmonary Physiology in chronic obstructive pulmonary disease." CT scanning can be used to aid in the diagnosis of chronic obstructive pulmonary disease (COPD). This project will attempt to correlate low attenuation areas (LAA%) and airway wall area (WA%) with pulmonary function as measured by spirometry. It will also explore the relationship between a combined index of chest radiograph abnormalities and pulmonary function. About 750 subjects in each arm of NLST who consent to spirometry will be enrolled.

Aims

1. To correlate the LAA% and WA% as determined by CT of patients enrolled in the NLST with their pulmonary function as measured by spirometry. 2. To explore the relationship between a combined index of chest radiograph abnormalities and pulmonary function.

Related Publications

• CT emphysema predicts thoracic aortic calcification in smokers with and without COPD.
  Dransfield MT, Huang F, Nath H, Singh SP, Bailey WC, Washko GR
  COPD. 2010 Dec; Volume 7 (Issue 6): Pages 404-10 PUBMED
• Quantitative assessment of bronchial wall attenuation with thin-section CT: An indicator of airflow limitation in chronic obstructive pulmonary disease.
  Yamashiro T, Matsuoka S, Estépar RS, Dransfield MT, Diaz A, Reilly JJ, Patz S, Murayama S, Silverman EK, Hatabu H, Washko GR
  AJR Am J Roentgenol. 2010 Aug; Volume 195 (Issue 2): Pages 363-9 PUBMED
• Quantitative CT measurement of cross-sectional area of small pulmonary vessel in COPD: correlations with emphysema and airflow limitation.
  Matsuoka S, Washko GR, Dransfield MT, Yamashiro T, San Jose Estepar R, Diaz A, Silverman EK, Patz S, Hatabu H
  Acad Radiol. 2010 Jan; Volume 17 (Issue 1): Pages 93-9 PUBMED
• Airway wall attenuation: a biomarker of airway disease in subjects with COPD.
  Washko GR, Dransfield MT, Estépar RS, Diaz A, Matsuoka S, Yamashiro T, Hatabu H, Silverman EK, Bailey WC, Reilly JJ
  J. Appl. Physiol. 2009 Jul; Volume 107 (Issue 1): Pages 185-91 PUBMED
• Gender differences in the severity of CT emphysema in COPD.
  Dransfield MT, Washko GR, Foreman MG, Estepar RS, Reilly J, Bailey WC
  Chest. 2007 Aug; Volume 132 (Issue 2): Pages 464-70 PUBMED