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Principal Investigator
Kyongtae Bae
University of Pittsburgh
Position Title
Professor of Radiology and Bioengineering
About this CDAS Project
NLST (Learn more about this study)
Project ID
Initial CDAS Request Approval
Apr 10, 2003
3D Morphometric Assessment of Temporal Changes in Lung Nodules
This project will evaluate and compare different CAD determinations of nodule volume using phantoms and clinical scans. It will also attempt to measure temporal changes in volume and compare CAD estimates of temporal changes with estimates made by radiologists. Finally, it will evaluate the probability of malignancy based on nodule growth rate as estimated by CAD and by radiologists.

1) To evaluate and compare CAD volumetric measurement methods on phantoms and selected test-set clinical CT scans. (Hypothesis: No significant variability in accuracy and reproducibility between different CAD methods in measuring lung nodule volumes.) 2) To measure temporal volumetric changes in nodules using CAD and compare them with semi-quantitative measurements by radiologists. (Hypothesis: The CAD measurements are significantly more reproducible than the 2D manual semi-quantitative measurements.) 3) To evaluate and compare the probability of malignancy based on the nodule growth rate estimated by the CAD and manual semi-quantitative measurements. Histology and clinical follow-up data from the NLST will be used as the gold standard. Hypothesis: The CAD method can estimate the probability of malignancy of a nodule more accurately and more time-efficiently than the manual method.

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