Adherence to Lifelines Diet Score (LLDS) is associated with lower lung cancer risk in 98,459 participants: a large prospective study
Principal Investigator
Name
Haitao Gu
Degrees
M.D.
Institution
The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1560
Initial CDAS Request Approval
May 14, 2024
Title
Adherence to Lifelines Diet Score (LLDS) is associated with lower lung cancer risk in 98,459 participants: a large prospective study
Summary
Based on the 2020 global cancer statistics, lung cancer remains the most prevalent malignant tumor among men and is one of the leading causes of cancer-related deaths(1). Additionally, the statistics revealed the incidence of lung cancer is greater within the elderly demographic in comparison to younger cohorts(1). Given the increasing global trend of population aging, it is anticipated that the burden of lung cancer on global health will intensify. In this context, the prevention of lung cancer has become paramount. Indeed, dietary strategies for cancer prevention have garnered significant attention in recent years.
Previous research has consistently shown that many diets are strongly correlated with a significant decrease in the risk of lung cancer (2). However, exploring the potential benefits of individual nutrient often overlooks the interconnected network of interactions among foods, disregarding the omnivorous nature of humans(3). To remedy the limitations of previous studies, some dietary indices have been developed to assess overall diet quality (4). Given that there are few dietary quality scores developed entirely based on food and scientific evidence, Petra C. Vinke et al. developed a dietary quality index, known as Lifelines Diet Score (LLDS) (5). Nevertheless, it is worth noting that there is no study specifically assessing the potential association between LLDS and the risk of lung cancer currently.
Therefore, our aim is to investigate whether adherence to LLDS can reduce the incidence and mortality of lung cancer in the American population.
References
1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-49.
2. Wei X, Zhu C, Ji M, Fan J, Xie J, Huang Y, et al. Diet and Risk of Incident Lung Cancer: A Large Prospective Cohort Study in UK Biobank. The American journal of clinical nutrition. 2021;114(6):2043-51.
3. Jacobs DR, Tapsell LC. Food synergy: the key to a healthy diet. The Proceedings of the Nutrition Society. 2013;72(2):200-6.
4. Gil Á, Martinez de Victoria E, Olza J. Indicators for the evaluation of diet quality. Nutricion hospitalaria. 2015;31 Suppl 3:128-44.
5. Vinke PC, Corpeleijn E, Dekker LH, Jacobs DR, Jr., Navis G, Kromhout D. Development of the food-based Lifelines Diet Score (LLDS) and its application in 129,369 Lifelines participants. European journal of clinical nutrition. 2018;72(8):1111-9.
Previous research has consistently shown that many diets are strongly correlated with a significant decrease in the risk of lung cancer (2). However, exploring the potential benefits of individual nutrient often overlooks the interconnected network of interactions among foods, disregarding the omnivorous nature of humans(3). To remedy the limitations of previous studies, some dietary indices have been developed to assess overall diet quality (4). Given that there are few dietary quality scores developed entirely based on food and scientific evidence, Petra C. Vinke et al. developed a dietary quality index, known as Lifelines Diet Score (LLDS) (5). Nevertheless, it is worth noting that there is no study specifically assessing the potential association between LLDS and the risk of lung cancer currently.
Therefore, our aim is to investigate whether adherence to LLDS can reduce the incidence and mortality of lung cancer in the American population.
References
1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-49.
2. Wei X, Zhu C, Ji M, Fan J, Xie J, Huang Y, et al. Diet and Risk of Incident Lung Cancer: A Large Prospective Cohort Study in UK Biobank. The American journal of clinical nutrition. 2021;114(6):2043-51.
3. Jacobs DR, Tapsell LC. Food synergy: the key to a healthy diet. The Proceedings of the Nutrition Society. 2013;72(2):200-6.
4. Gil Á, Martinez de Victoria E, Olza J. Indicators for the evaluation of diet quality. Nutricion hospitalaria. 2015;31 Suppl 3:128-44.
5. Vinke PC, Corpeleijn E, Dekker LH, Jacobs DR, Jr., Navis G, Kromhout D. Development of the food-based Lifelines Diet Score (LLDS) and its application in 129,369 Lifelines participants. European journal of clinical nutrition. 2018;72(8):1111-9.
Aims
To investigate whether adherence to LLDS can reduce the incidence and mortality of lung cancer.
Collaborators
Yangpiaoyi Shi, Yaxu Wang, Hang Liu, Qi Wei, Yahui Jiang, Zhiyong Zhu, Haitao Gu, Linglong Peng et al.
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ling Xiang
Department of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.