Study
PLCO
(Learn more about this study)
Project ID
PLCO-1547
Initial CDAS Request Approval
Apr 29, 2024
Title
Diet and risks of lung cancer
Summary
Unhealthy diets are recognized as a major determinant of the occurrence of Non-communicable diseases (NCDs) and constitutes a serious threat to global health systems. Epidemiological studies have found associations between the diet and a higher risk of all-cause mortality, all-cause cancer, irritable bowel disease, metabolic syndrome, obesity, and hypertension. But the longitudinal effects of diet on lung cancer and its subtypes remain controversial. To clarify the relationship, we aim to conduct a prospective analysis of associations of lung cancer risk with diet in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort. The clinical data and lifestyle were collected. Dietary intakes was assessed through a validated Diet History Questionnaire (DHQ). Primary outcome is the association between diet and all-cause lung cancer, non-small cell lung cancer (NSCLC), and small cell lung cancer (SCLC). Multivariable Cox regression was used to access the association between consumption of different food such as ultra-processed foods, and whole grain food and lung cancer under adjustment for known risk factors. These variables are available in the PLCO trial. Our result will benefit the treatment and prevention of clinical events in lung cancer patients and may find the new intervention target and mechanism
Aims
1.Our study seeks to evaluate whether food intake such as ultra-processed foods, and whole grain food was associated with lung cancer risk using the data from both the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial with longitudinal follow-up and incorporated a detailed review of food intake and all medical records.
2. Restricted cubic spline regression was used to calculate the potential dose-response non-linear association between UPF and all-cause lung cancer, NSCLC, and SCLC. Subgroup analysis were conducted to confirm the robustness of the association.
Collaborators
1.Wei Zhou Chongqing University Cancer Hospital, Chongqing, China, 400030
2.Junhan Zhao Harvard T. H. Chan School of Public Health and Harvard Medical School, Boston, MA, USA, 02115
