Risk stratification for bladder cancer among heavy smokers in the National Lung Screening Trial

Principal Investigator

Name
Timothy Church

Degrees
PhD

Institution
University of Minnesota

Position Title
Professor, Environmental Health Sciences

Email
trc@cccs.umn.edu

About this CDAS Project

Study
NLST (Learn more about this study)

Project ID
201207-0029

Initial CDAS Request Approval
Jul 31, 2012

Title
Risk stratification for bladder cancer among heavy smokers in the National Lung Screening Trial

Summary
Presence of microhematuria has been used to detect early bladder cancer. Smoking is a risk factor for bladder cancer, as is advancing age and male sex. The primary aim of the study is to combine detailed smoking history, age, sex, and other data collected at baseline on NLST subjects to develop a prediction algorithm to be used to stratify individuals by risk of bladder cancer. This stratification could be used for several purposes, the most immediate one being to determine the feasibility of a randomized trial of bladder cancer screening in high risk individuals. We hope that a high enough risk subgroup could be identified to warrant screening, based on earlier modeling done on the risk necessary for a trial [Vickers, A. J., C. Bennette, et al. (2012). Who should be included in a clinical trial of screening for bladder cancer?: A decision analysis of data from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Cancer].

Collaborators

Chris Berg
Grant Izmirlian
Yair Lotan