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Principal Investigator
Linglong Peng
The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Position Title
About this CDAS Project
PLCO (Learn more about this study)
Project ID
Initial CDAS Request Approval
Mar 27, 2024
Adherence to the EAT-Lancet dietary pattern reduces the risk of renal cancer in the PLCO Cancer Screening Trial
Renal cancer ranks among the top ten most prevalent cancers globally. According to the 2020 global cancer statistics report, there were approximately 401,000 new cases of renal cancer diagnosed and 175,000 deaths attributed to this malignancy(1). While recognized risk factors such as obesity, smoking, hypertension, and diabetes make substantial contributions to renal cancer risk(2), these do not account for the entire spectrum of risk factors. Indeed, accumulating evidence suggests that dietary factors may play a pivotal role as important risk determinants for renal cancer(3).
The EAT-Lancet diet (ELD), is a dietary framework developed by the EAT-Lancet Commission on Food, Planet, and Health in 2019. This dietary recommends increased consumption of vegetables, fruits, unsaturated oils, legumes, nuts, whole grains, and fish, while advocating for limited intake of red and processed meats, dairy products, eggs, and added sugars(4). Several components of the EAT-Lancet diet have been associated with a reduced risk of renal cancer, including higher intakes of antioxidants, dietary fiber, and polyunsaturated fatty acids, coupled with lower consumption of red and processed meats(5). Furthermore, adherence to the EAT-Lancet diet may mitigate the risk of obesity and type 2 diabetes mellitus(6), which are established risk factors for renal cancer.
Nevertheless, the association between the EAT-Lancet diet and the risk of renal cancer remains unclear. Thus, we conducted this study using prospective data from the PLCO trial.

1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: a cancer journal for clinicians. 2021;71(3):209-49.
2. Gluba-Brzózka A, Rysz J, Ławiński J, Franczyk B. Renal Cell Cancer and Obesity. International journal of molecular sciences. 2022;23(6).
3. Dalmartello M, Bravi F, Serraino D, Crispo A, Ferraroni M, La Vecchia C, et al. Dietary Patterns in Italy and the Risk of Renal Cell Carcinoma. Nutrients. 2020;12(1).
4. Stubbendorff A, Sonestedt E, Ramne S, Drake I, Hallström E, Ericson U. Development of an EAT-Lancet index and its relation to mortality in a Swedish population. The American journal of clinical nutrition. 2022;115(3):705-16.
5. Farvid MS, Sidahmed E, Spence ND, Mante Angua K, Rosner BA, Barnett JB. Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies. European journal of epidemiology. 2021;36(9):937-51.
6. Lin X, Wang S, Huang J. The Association between the EAT-Lancet Diet and Diabetes: A Systematic Review. Nutrients. 2023;15(20).

To investigate whether adherence to the EAT-Lancet diet is associated with renal risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.


Linglong Peng, Haitao Gu, Yunhao Tang, Hang Liu, Zhiyong Zhu, Qi Wei, Yi Xiao, Xiaorui Ren, Bo Sheng, Peng Zhu, Yi Li, Yaxu Wang, et al. Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ling Xiang, Department of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.