Factors associated with small aggressive NSCLC abnormal suspicious CXR screens.
Principal Investigator
Name
Martin Tammemagi
Degrees
DVM; MSc; PhD
Institution
Henry Ford Health System
Position Title
Professor of Epidemiology
About this CDAS Project
Study
NLST
(Learn more about this study)
Project ID
201110-0017
Initial CDAS Request Approval
Oct 25, 2011
Title
Factors associated with small aggressive NSCLC abnormal suspicious CXR screens.
Summary
The general aim of this study is to identify factors associated with small lung cancers that have developed distant spread, and to attempt to validate previous finding from a Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial ancillary study. In the PLCO study, it was found that women with a family history of lung cancer were at 12 fold greater risk of developing a small aggressive non-small cell lung cancer (SA-NSCLC), compared to men without a family history of lung cancer. These findings were published
Tammemagi CM, Freedman MT, Church TR, et al. Factors associated with human small aggressive non small cell lung cancer. Cancer Epidemiol Biomarkers Prev 2007;16(10):2082-9.
The National Lung Screening Trial provides us with the ability to attempt to confirm these finding and in addition evaluate additional parameters not available in the PLCO. In particular, the distribution of tumor sizes associated with distant spread can be studied, as can the relationship between SA-NSCLC and interval cancers.
Collaborators
Matthew Freedman