Comparison of net endogenous acid production from dietary self-report instruments against recovery biomarker-derived measures
Epidemiological studies of nutrition have made important contributions to understanding the relationship between dietary factors and disease. Such studies rely upon tools based on self-reported dietary intake which are subject to measurement error and require validation. Advances in understanding the link between dietary acid load and health have been hampered by the limited ability to assess dietary acid load measures such as net endogenous acid production (NEAP) in the community. NEAP derived from recovery biomarkers collected from urine excretion represent an objective measure of NEAP.
The Automated Self-Administered 24-hour Dietary Assessment Tool (ASA24) is a freely available, web-based, automatically coded, self-administered recall instrument (3). How well NEAP from ASA24 and other self-reported dietary assessment tools (e.g., Diet History Questionnaire (DHQ) II; 4-d food records) compares with NEAP derived from biomarkers is unclear (4, 5).
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To compare NEAP from self-reported dietary assessment tools (e.g., ASA24, DHQ II, and 4-d food records) against NEAP derived from urine biomarkers (e.g., calculated from 24-h urine potassium and protein excretion).
Matthew Abramowitz, M.D., M.S. (Albert Einstein College of Medicine)
Emma Stinson, M.P.H. (National Institute of Diabetes and Digestive and Kidney Diseases)
Jonathan Krakoff, M.D. (National Institute of Diabetes and Digestive and Kidney Diseases)
Heather Bowles, Ph.D. (National Cancer Institute)
Kevin Dodd, Ph.D. (National Cancer Institute)