Skip to Main Content

An official website of the United States government

Principal Investigator
Name
Christopher Towe
Degrees
MD
Institution
Department of Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University
Position Title
Associate Professor of Surgery
Email
About this CDAS Project
Study
NLST (Learn more about this study)
Project ID
NLST-1196
Initial CDAS Request Approval
Feb 26, 2024
Title
Long-Term Mortality Patterns Following Lung Cancer Subtype Resections: A Comparative Analysis of NLST Data
Summary
This study aims to analyze the long-term mortality patterns among individuals who underwent different lung cancer subtype resections, including wedge resection, lobe resection, and those without lung cancer, based on data from the National Lung Screening Trial (NLST). By examining causes of death in these subgroups, particularly focusing on non-cancer-related mortality, the study seeks to elucidate potential differences in survival outcomes over time. Adjusting for relevant risk factors, the analysis aims to provide insights into the comparative effectiveness of different surgical approaches in lung cancer management and their impact on overall mortality.
Aims

• Compare causes of death among NLST participants who underwent wedge resection, lobe resection, and those without lung cancer, focusing on long-term mortality patterns.

• Evaluate non-cancer-related mortality rates over an extended follow-up period among individuals who underwent different lung cancer subtype resections.

• Assess the association between lung cancer subtype resection type and long-term survival outcomes, adjusting for relevant risk factors such as age, smoking history, comorbidities, and tumor characteristics.

• Investigate potential disparities in long-term mortality outcomes among different demographic groups within each resection subtype category.

• Identify predictors of non-cancer-related mortality following lobe resection compared to other surgical approaches, aiming to inform personalized treatment strategies and improve postoperative care for lung cancer patients.

Collaborators

Christina Boutros
Aria Bassiri
Victoria Wu
Jillian Sinopoli
Leonidas Tapias
Phillip Linden
Boxiang Jiang