Estimation of Overdiagnosis Bias in the NLST

Principal Investigator

Name
Edward Patz, Jr.

Degrees
MD

Institution
Duke University Medical Center

Position Title
Principal Investigator

Email
patz0002@mc.duke.edu

About this CDAS Project

Study
NLST (Learn more about this study)

Project ID
201207-0026

Initial CDAS Request Approval
Jul 27, 2012

Title
Estimation of Overdiagnosis Bias in the NLST

Summary
This study will determined the magnitude of overdiagnosis with CT screening using data from the NLST, and then applied a convolution model to estimate the impact on a broader mass screening program. These data will be useful in helping to understanding the risks and limitations of CT, but may be useful in understanding the natural history of this disease.

Collaborators

William Black
Constantine Gatsonis
Paul Pinsky
Denise Aberle
Christine Berg
Tim Church
Others

Related Publications

• Overdiagnosis in low-dose computed tomography screening for lung cancer.
  Patz EF, Pinsky P, Gatsonis C, Sicks JD, Kramer BS, Tammemägi MC, Chiles C, Black WC, Aberle DR, NLST Overdiagnosis Manuscript Writing Team
  JAMA Intern Med. 2014 Feb; Volume 174 (Issue 2): Pages 269-74 PUBMED