yadong Li

M.M

The Second Affiliated Hospital of chongqing medical university

Dr

PLCO (Learn more about this study)

PLCO-1407

Dec 4, 2023

Systematically evaluation of diet and behavioral factors associated with kidney cancer incidence and mortality in the PLCO Screening Trial

Kidney cancer (KC) is the most common malignant cancer of the urinary system, with 431,288 new cases and 179,368 new deaths worldwide in 2020 (1). The established risk factors for development of KC include excess body weight, history of hypertension, and smoking, which cannot fully explain KC incidence increases. Therefore, it is becoming vital importance to identify modifiable risk factors (2,3). Previously prospective cohorts suggested that there may be great promise for fruit and vegetables in KC prevention (4, 5), suggesting diet may play a role in KC etiology directly and/or indirectly. However, the limited evidence from individual studies was not fully consistent (6-8). Therefore, we plan to perform a systematic evaluation of dietary and behavioral factors associated with KC incidence and survival.
The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, which was a randomized multicenter controlled study and included diet and behavioral information is also available in questionnaires, such as Baseline Questionnaire (BQ), Dietary History Questionnaire (DHQ), Dietary Questionnaire (DQX) and so on, provided a comprehensive information for KC incidence and mortality analysis.