Association between Oxidative Balance Score and colorectal cancer risk in 98,395 participants: Results from a prospective study
Principal Investigator
Name
Ling Xiang
Institution
The Second Affiliated Hospital of Chongqing Medical University
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1296
Initial CDAS Request Approval
Aug 22, 2023
Title
Association between Oxidative Balance Score and colorectal cancer risk in 98,395 participants: Results from a prospective study
Summary
Colorectal cancer (CRC) is a multifactorial disease that ranks third in morbidity but second in mortality. In 2020, it is estimated that colorectal cancer contributed to approximately one in 10 cancer cases and deaths(1). Both dietary factors and lifestyle factors play an important role in the occurrence and development of colorectal cancer, which can be used to prevent colorectal cancer(2,3). Oxidative Balance Score (OBS) is a tool that allows us to assess an individual's antioxidant status by considering both pro-oxidant and antioxidant components of dietary and lifestyle factors(4–6). However, there is no consistent epidemiological evidence to link this score to colorectal cancer risk. For example, previous studies found that a higher OBS was associated with lower risk of colorectal cancer(7), but another article suggested that total antioxidant capacity of food was not associated with colorectal cancer risk(8). We conducted a large-scale, prospective investigation to assess the relationship between oxidative stress and the risk of colorectal cancer using OBS among Americans.
Reference:
1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA A Cancer J Clin (2021) 71:209–249. doi: 10.3322/caac.21660
2. Zhou E, Rifkin S. Colorectal Cancer and Diet. Gastroenterology Clinics of North America (2021) 50:101–111. doi: 10.1016/j.gtc.2020.10.012
3. Botteri E, Peveri G, Berstad P, Bagnardi V, Chen SLF, Sandanger TM, Hoff G, Dahm CC, Antoniussen CS, Tjønneland A, et al. Changes in Lifestyle and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition. Am J Gastroenterol (2023) 118:702–711. doi: 10.14309/ajg.0000000000002065
4. Lakkur S, Judd S, Bostick RM, McClellan W, Flanders WD, Stevens VL, Goodman M. Oxidative stress, inflammation, and markers of cardiovascular health. Atherosclerosis (2015) 243:38–43. doi: 10.1016/j.atherosclerosis.2015.08.032
5. Hernández-Ruiz Á, García-Villanova B, Guerra-Hernández E, Amiano P, Ruiz-Canela M, Molina-Montes E. A Review of A Priori Defined Oxidative Balance Scores Relative to Their Components and Impact on Health Outcomes. Nutrients (2019) 11:774. doi: 10.3390/nu11040774
6. Hernández-Ruiz Á, García-Villanova B, Guerra-Hernández EJ, Carrión-García CJ, Amiano P, Sánchez M-J, Molina-Montes E. Oxidative Balance Scores (OBSs) Integrating Nutrient, Food and Lifestyle Dimensions: Development of the NutrientL-OBS and FoodL-OBS. Antioxidants (2022) 11:300. doi: 10.3390/antiox11020300
7. Dash C, Bostick RM, Goodman M, Flanders WD, Patel R, Shah R, Campbell PT, McCullough ML. Oxidative Balance Scores and Risk of Incident Colorectal Cancer in a US Prospective Cohort Study. Am J Epidemiol (2015) 181:584–594. doi: 10.1093/aje/kwu318
8. Mekary RA, Wu K, Giovannucci E, Sampson L, Fuchs C, Spiegelman D, Willett WC, Smith-Warner SA. Total antioxidant capacity intake and colorectal cancer risk in the Health Professionals Follow-up Study. Cancer Causes Control (2010) 21:1315–1321. doi: 10.1007/s10552-010-9559-9
Reference:
1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA A Cancer J Clin (2021) 71:209–249. doi: 10.3322/caac.21660
2. Zhou E, Rifkin S. Colorectal Cancer and Diet. Gastroenterology Clinics of North America (2021) 50:101–111. doi: 10.1016/j.gtc.2020.10.012
3. Botteri E, Peveri G, Berstad P, Bagnardi V, Chen SLF, Sandanger TM, Hoff G, Dahm CC, Antoniussen CS, Tjønneland A, et al. Changes in Lifestyle and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition. Am J Gastroenterol (2023) 118:702–711. doi: 10.14309/ajg.0000000000002065
4. Lakkur S, Judd S, Bostick RM, McClellan W, Flanders WD, Stevens VL, Goodman M. Oxidative stress, inflammation, and markers of cardiovascular health. Atherosclerosis (2015) 243:38–43. doi: 10.1016/j.atherosclerosis.2015.08.032
5. Hernández-Ruiz Á, García-Villanova B, Guerra-Hernández E, Amiano P, Ruiz-Canela M, Molina-Montes E. A Review of A Priori Defined Oxidative Balance Scores Relative to Their Components and Impact on Health Outcomes. Nutrients (2019) 11:774. doi: 10.3390/nu11040774
6. Hernández-Ruiz Á, García-Villanova B, Guerra-Hernández EJ, Carrión-García CJ, Amiano P, Sánchez M-J, Molina-Montes E. Oxidative Balance Scores (OBSs) Integrating Nutrient, Food and Lifestyle Dimensions: Development of the NutrientL-OBS and FoodL-OBS. Antioxidants (2022) 11:300. doi: 10.3390/antiox11020300
7. Dash C, Bostick RM, Goodman M, Flanders WD, Patel R, Shah R, Campbell PT, McCullough ML. Oxidative Balance Scores and Risk of Incident Colorectal Cancer in a US Prospective Cohort Study. Am J Epidemiol (2015) 181:584–594. doi: 10.1093/aje/kwu318
8. Mekary RA, Wu K, Giovannucci E, Sampson L, Fuchs C, Spiegelman D, Willett WC, Smith-Warner SA. Total antioxidant capacity intake and colorectal cancer risk in the Health Professionals Follow-up Study. Cancer Causes Control (2010) 21:1315–1321. doi: 10.1007/s10552-010-9559-9
Aims
Our objective is to investigate whether adherence to an oxidatively balanced diet and lifestyle pattern is associated with a reduced risk of developing colorectal cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Collaborators
Linglong Peng, Yaxu Wang, Haitao Gu, Hongmei He, et al. Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.