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Principal Investigator
Name
Ruofan Zhang
Degrees
Ph.D.
Institution
Institute of Automation, CAS
Position Title
researcher
Email
About this CDAS Project
Study
NLST (Learn more about this study)
Project ID
NLST-1080
Initial CDAS Request Approval
Jun 2, 2023
Title
Survival Analysis based on WSI images
Summary
Medical professionals may find it easier to diagnose and treat cancer patients using image-based survival prediction algorithms. The huge whole slide images (WSIs), made possible by the development of digital pathology technologies, offer greater resolution and more information for diagnosis. However, the computational impossibility of most models would be caused by gigabyte- or even terabyte-sized WSIs.
Aims

To this purpose, most of the available models only employ a pre-selected selection of essential patches or patch clusters as input, perhaps discarding some crucial morphological data, as opposed to using the entire WSIs. In order to properly utilize the whole WSI information, we present a novel survival analysis approach in this work. We demonstrate that using a Vision Transformer (ViT) backbone and the associated convolution operations is a successful strategy for enhancing prediction performance. The most prominent patches and distinctive morphology traits are also identified using a post-hoc manner that is understandable, which improves the model's accuracy and makes it simpler for people to understand the results.
Evaluations on two sizable cancer datasets demonstrate that our suggested model is more useful and easier to understand for predicting survival. Upon approval, we would release the code for general use.

Collaborators

liwen zhang
Institute of Automation, CAS