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Principal Investigator
Hao Wang
Zhengzhou University School of Public Health
Position Title
Associate Professor
About this CDAS Project
PLCO (Learn more about this study)
Project ID
Initial CDAS Request Approval
May 30, 2023
Relationship between dietary habits and the risk and mortality of digestive system tumors
The digestive system consists of two parts: the digestive tract and the digestive glands. The digestive tract includes the oral cavity, pharynx, esophagus, stomach, small intestine and large intestine. Digestive system tumors mainly include gastrointestinal tumors, liver cancer and pancreatic cancer. Esophageal cancer is the eighth most common type of cancer worldwide and constitutes the sixth leading cause of cancer deaths. Colorectal cancer (CRC) is the most diagnosed and deadliest gastrointestinal cancer. According to 2020 statistics, there were 1,806,590 new cancer cases and 606,520 cancer deaths in the United States, with gastrointestinal cancers being one of the leading causes of death. Gastrointestinal tract tumors seriously affect the quality of life of patients. Primary liver cancer is the sixth most commonly diagnosed cancer and the third leading cause of cancer death worldwide in 2020, with a large number of patients and a high lethality rate. Pancreatic cancer is one of the leading causes of cancer death worldwide, with a poor prognosis and rapid progression.
Digestive tumors is closely related to dietary factors, but the impact of certain or combined nutrients supplementation methods and dietary habits on disease development and prognosis is unclear.
Our laboratory has been studying the nutrition related diseases for many years. In this study, we will estimate the association between dietary habits and the risk of developing digestive system tumors in the PLCO cancer screening trial. We will use different statistical analysis methods and adjust for multiple potential confounders for the analysis. We anticipate that these findings may further our understanding of the role of dietary habits and nutrients intake in digestive system tumors.

1. Prospectively evaluate the association between various nutrients on digestive system tumors risk and mortality.
2. Assess the association of nutrient sources and food processing practices on the risk of digestive system tumors and mortality.
3. Investigate the impact of trace elements intake in digestive system tumors risk and mortality by excluding the confounders of life habits (lifestyle, smoking, dietary intake, etc.).


Siyue Li, Zhengzhou University
Yanna Shang, Zhengzhou University
Zhiguang Ping, Zhengzhou University