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Principal Investigator
Ling Xiang
Department of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Position Title
About this CDAS Project
PLCO (Learn more about this study)
Project ID
Initial CDAS Request Approval
May 30, 2023
Adherence to the Dietary Approaches to Stop Hypertension eating pattern reduces the risk of head and neck cancer in the PLCO Cancer Screening Trial
Globally, head and neck cancer (HNC) was the seventh most prevalent form of malignancy, with roughly 930,000 new cases and 460,000 fatalities in 2020, accounting for 4.9% of cancer diagnoses and 4.7% of cancer-related deaths, respectively(1). Dietary Approaches to Stop Hypertension (DASH) pattern is a dietary pattern that promotes the consumption of fruits, vegetables, grains, low-fat dairy products, nuts and legumes while restricting the intake of sodium, sugar-sweetened beverages, and red and processed meat. It is composed of several elements that have been identified as protective factors for HNC, such as fruits, vegetables, and grains(2), while simultaneously curtailing the intake of harmful components such as processed meat(3). Furthermore, the DASH diet is recognized to play a role in mitigating obesity, reducing oxidative stress, and alleviating chronic inflammation(4). Obesity is a significant risk factor for HNC(5), and oxidative damage and chronic inflammation are commonly shared pathways for various cancers, including HNC. In actuality, the DASH diet has been found to be beneficial in preventing a variety of cancers, including but not limited to breast cancer, gastric cancer, and lung cancer(6). Nevertheless, the association between DASH diet and the risk of HNC remains unclear. Thus, we conducted this study using prospective data from the PLCO trial.

1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: a cancer journal for clinicians. 2021;71(3):209-49.
2. Lam TK, Cross AJ, Freedman N, Park Y, Hollenbeck AR, Schatzkin A, et al. Dietary fiber and grain consumption in relation to head and neck cancer in the NIH-AARP Diet and Health Study. Cancer causes & control : CCC. 2011;22(10):1405-14.
3. Perloy A, Maasland DHE, van den Brandt PA, Kremer B, Schouten LJ. Intake of meat and fish and risk of head-neck cancer subtypes in the Netherlands Cohort Study. Cancer causes & control : CCC. 2017;28(6):647-56.
4. Aleksandrova K, Koelman L, Rodrigues CE. Dietary patterns and biomarkers of oxidative stress and inflammation: A systematic review of observational and intervention studies. Redox biology. 2021;42:101869.
5. Wang K, Yu XH, Tang YJ, Tang YL, Liang XH. Obesity: An emerging driver of head and neck cancer. Life sciences. 2019;233:116687.
6. Myneni AA, Giovino GA, Millen AE, LaMonte MJ, Wactawski-Wende J, Neuhouser ML, et al. Indices of Diet Quality and Risk of Lung Cancer in the Women's Health Initiative Observational Study. The Journal of nutrition. 2021;151(6):1618-27.

To investigate whether adherence to the DASH diet is associated with head and neck risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.


Zhiyong Zhu 1, Linglong Peng 1, Haitao Gu 1, Yi Xiao 1, Haoyun Luo 1, Zhiquan Xu 1, Hongmei He 1, Yaxu Wang 1, Ling Xiang 2
1 Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
2 Department of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.