Linglong Peng

Ph.D.

Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Dr.

PLCO (Learn more about this study)

PLCO-1231

May 30, 2023

The compliance to EAT-Lancet diet and risk of colorectal cancer: a prospective PLCO cohort study

Colorectal cancer (CRC) is an important cause of cancer burden in the United States, it is reported to be the third most commonly diagnosed cancer and the third cause of cancer‐associated death in both men and women[1]. In western countries, diet is one of the most important risk factors for CRC, making it a possible preventive target[1]. Recently, a new dietary pattern has been proposed, named EAT-Lancet diet (ELD), which is a scientifically optimized diet for nutrition and certain environmental indicators[3]. ELD may greatly benefit human health. For example, adherence to ELD can reduce annual mortality by 19.0-23.6%[5], and can reduce the risk of cardiovascular disease and diabetes[4–7]. Berthy F et al. found that adherence to ELD reduced CRC risk by 10% in a French Web-based prospective cohort, but with no statistically significant (HRQ5vs.Q1: 0.90; 95% CI: 0.58, 1.41; P-trend = 0.52)[7]. To date, researches on the ELD and CRC risk are lack, and studies by sex and subsites are scarce. Therefore, we conducted this analysis to explore the relationship between ELD adherence and CRC incidence and deaths in 98,415 subjects aged 55 to 74 years from the Prostate, Lung, Colorectal, and Ovarian (PLCO) cohort. We conducted studies in men and women, separately.
Reference:
[1] Siegel RL, Wagle NS, Cercek A, Smith RA, Jemal A. Colorectal cancer statistics, 2023. CA Cancer J Clin 2023. https://doi.org/10.3322/caac.21772.
[2] Kuipers EJ, Grady WM, Lieberman D, Seufferlein T, Sung JJ, Boelens PG, et al. COLORECTAL CANCER. Nat Rev Dis Primers 2015;1:15065. https://doi.org/10.1038/nrdp.2015.65.
[3] Willett W, Rockström J, Loken B, Springmann M, Lang T, Vermeulen S, et al. Food in the Anthropocene: the EAT-Lancet Commission on healthy diets from sustainable food systems. Lancet 2019;393:447–92. https://doi.org/10.1016/S0140-6736(18)31788-4.
[4] Lazarova SV, Sutherland JM, Jessri M. Adherence to emerging plant-based dietary patterns and its association with cardiovascular disease risk in a nationally representative sample of Canadian adults. Am J Clin Nutr 2022;116:57–73. https://doi.org/10.1093/ajcn/nqac062.
[5] Ibsen DB, Christiansen AH, Olsen A, Tjønneland A, Overvad K, Wolk A, et al. Adherence to the EAT-Lancet Diet and Risk of Stroke and Stroke Subtypes: A Cohort Study. Stroke 2022;53:154–63. https://doi.org/10.1161/STROKEAHA.121.036738.
[6] Cacau LT, Benseñor IM, Goulart AC, Cardoso L de O, Santos I de S, Lotufo PA, et al. Adherence to the EAT-Lancet sustainable reference diet and cardiometabolic risk profile: cross-sectional results from the ELSA-Brasil cohort study. Eur J Nutr 2023;62:807–17. https://doi.org/10.1007/s00394-022-03032-5.
[7] Berthy F, Brunin J, Allès B, Fezeu LK, Touvier M, Hercberg S, et al. Association between adherence to the EAT-Lancet diet and risk of cancer and cardiovascular outcomes in the prospective NutriNet-Santé cohort. Am J Clin Nutr 2022;116:980–91. https://doi.org/10.1093/ajcn/nqac208.