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Principal Investigator
Yifu Zeng
The Second Affiliated Hospital of Fujian Medical University
Position Title
About this CDAS Project
PLCO (Learn more about this study)
Project ID
Initial CDAS Request Approval
May 4, 2023
Association of Low-Carbohydrate Ketogenic Diet with Prostate Cancer in the PLCO Screening Trial
Prostate cancer is the most diagnosed cancer among men in the United States and the second most fatal malignant cancer among men [1]. The discovery of new dietary interventions for prostate cancer is significant. The low-carbohydrate ketogenic diet (LCKD) may help delay prostate cancer growth due to its ability to reduce serum insulin and IGF-1 levels.In this regard, however, the relationship between diet and cancer development and/or growth remains highly complex (including: LCKD induces specific metabolic properties that may significantly increase body energy expenditure and exacerbate malignant changes in cancer) [2] and effective treatment for men with advanced disease is lacking [3]. As prostate cancer patients often have metabolic-related diseases such as diabetes after dietary treatment, further studies are needed to determine the precise threshold of carbohydrate content according to the degree of and the type of concomitant disease in order to ensure optimal health while maintaining tumor control [4].

[1] Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2018. CA A Cancer J. Clin. 2018;68:7–30. doi: 10.3322/caac.21442. [PubMed] [CrossRef] [Google Scholar]
[2]Schutz Y, Montani JP, Dulloo AG. Low-carbohydrate ketogenic diets in body weight control: A recurrent plaguing issue of fad diets? Obes Rev. 2021 Mar;22 Suppl 2:e13195. doi: 10.1111/obr.13195. Epub 2021 Jan 20. PMID: 33471427.
[3]John C. Mavropoulos, William B. Isaacs, Salvatore V. Pizzo, Stephen J. Freedland,
Is there a role for a low-carbohydrate ketogenic diet in the management of prostate cancer?,Urology,Volume68,Issue1,2006,Pages15-18,ISSN0090-4295,
[4]Masko EM, Thomas JA 2nd, Antonelli JA, Lloyd JC, Phillips TE, Poulton SH, Dewhirst MW, Pizzo SV, Freedland SJ. Low-carbohydrate diets and prostate cancer: how low is "low enough"? Cancer Prev Res (Phila). 2010 Sep;3(9):1124-31. doi: 10.1158/1940-6207.CAPR-10-0071. Epub 2010 Aug 17. PMID: 20716631; PMCID: PMC3757152.

1. To explore whether LCKD is associated with a reduced risk of prostate cancer
2. Further analysis to determine the precise threshold of carbohydrate intake


Chunmei Fan(Department of Laboratorial Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou)
Qingquan Chen, Ling Yao, Kang Yang, Xiyu Wu(Fujian Medical University, Fuzhou)