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Principal Investigator
Yixiang Zhang
The Second Affiliated Hospital of Fujian Medical University
Position Title
About this CDAS Project
PLCO (Learn more about this study)
Project ID
Initial CDAS Request Approval
May 4, 2023
Association between ketogenic diet and lung cancer
Lung cancer is the leading cause of cancer-related mortality worldwide and accounts for almost 25% of all cancer fatalities. Despite recent advances in diagnosis and treatment, the five-year survival rate remains poor at 22%[1].The ketogenic diet is characterised by its very low carbohydrate, medium protein and high fat content. Such a dietary pattern leads to a decrease in glucose and an increase in ketone body production in the body. A possible anti-tumour mechanism of the ketogenic diet is that tumour cells cannot use ketones as their dietary energy source in the absence of glucose, resulting in reduced glycolysis and tumour proliferation[2]. Its efficacy in inhibiting tumour progression and prolonging survival in mice with metastatic cancer has been demonstrated and supports the anti-tumour effects of a ketogenic diet in various types of cancer, including lung cancer[2]. We plan to conduct a study to determine the association between the ketogenic diet and lung cancer risk and to explore whether this association is influenced by other factors.

[1]Forder A, Zhuang R, Souza VGP, et al. Mechanisms Contributing to the Comorbidity of COPD and Lung Cancer. Int J Mol Sci. 2023;24(3):2859. Published 2023 Feb 2. doi:10.3390/ijms24032859
[2]Tamraz M, Al Ghossaini N, Temraz S. The Ketogenic Diet in Colorectal Cancer: A Means to an End. Int J Mol Sci. 2023;24(4):3683. Published 2023 Feb 12. doi:10.3390/ijms24043683

1.To explore the link between the ketogenic diet and lung cancer.
2.Conducting subgroup analyses to explore whether the association between ketogenic diet and lung cancer risk was modified by other factors.
3.To provide dietary advice for the treatment or prevention of lung cancer.


Xiaoyang Chen(The Second Affiliated Hospital of Fujian Medical University, Quanzhou)
Yifu Zeng (Cyberspace Institute of Advanced Technology, Guangzhou University, Guangzhou)
Qingquan Chen, Kang Yang, Ling Yao, Xinru Shu(Fujian Medical University, Fuzhou)