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Principal Investigator
Name
Meng Zhou
Degrees
Ph.D.
Institution
Institute of Biomedical Big Data, Wenzhou Medical University
Position Title
Deputy Director
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCOI-1219
Initial CDAS Request Approval
May 8, 2023
Title
Improving prognosis prediction of ovarian cancer and identify homologous recombination deficient phenotype patients from whole slide images using deep learning
Summary
This project aim to develop a deep learning model to obtain pathomic features from pathological images of ovarian cancer patients, which will be used to assess the prognosis of ovarian cancer patients and identify patients with homologous recombination-deficient phenotypes. Ultimately, derivation histopathological features associated with prognosis and homologous recombination-deficient phenotypes.
Aims

1.To develop a deep learning-based approach for extracting pathological features from histological images of ovarian cancer patients.
2.To investigate the prognostic value of these features in predicting the clinical outcomes of ovarian cancer patients.
3.To develop a predictive model using the extracted features to identify patients with homologous recombination deficiency phenotype.
4.To evaluate the performance of the proposed model using an independent validation cohort of ovarian cancer patients.
5.To derivation histopathological features associated with prognosis and homologous recombination-deficient phenotypes.

Collaborators

Meng Zhou, School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
Jie Sun, School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
Zijian Yang, School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
Yibo Zhang, School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
Liwei Chen, School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
Liujin Zhang, School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
Yitong Zheng, School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China