Linglong Peng

M.D.

Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Dr.

PLCO (Learn more about this study)

PLCO-1215

May 2, 2023

Adherence to the Paleolithic diet and Paleolithic-like lifestyle reduce the risk of colorectal and lung cancer in the United States: A prospective cohort study

Colorectal cancer (CRC) is a significant global public health concern, ranking as the third most common cancer in men and the second most common cancer in women (1). In the United States alone, CRC is estimated to cause 150,000 new cases and 50,000 deaths in 2023 (2). Adopting a healthy diet and lifestyle may play a crucial role in reducing the incidence of colorectal cancer. In recent years, there has been growing interest in the Paleolithic Diet (PD) and Paleolithic-Like Lifestyle (PLL) within the field of nutritional epidemiology (3). Many studies have used the PD score alone or in combination with lifestyle factors (i.e., PLL score) to analyze the incidence of chronic diseases (4,5), cancer (6), and mortality (7). To our knowledge, there are still limited studies to investigate the association between PD and PLL adherence and the incidence of CRC and its anatomical subsites. Thus, in this study, we aimed to prospectively investigate the potential association between PD and PLL adherence and CRC incidence in American adults, and to examine whether this association varies by anatomical subsites of CRC.

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