Association of dietary and supplemental antioxidant intake with ovarian cancer risk
Principal Investigator
Name
Yifu Zeng
Degrees
Ph.D.
Institution
The Second Affiliated Hospital of Fujian Medical University
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1198
Initial CDAS Request Approval
Apr 19, 2023
Title
Association of dietary and supplemental antioxidant intake with ovarian cancer risk
Summary
Globally, ovarian cancer is the seventh most common cancer in women and the eighth leading cause of cancer death, with a five-year survival rate of less than 45%[1]. The balance between free radicals and antioxidants is necessary for proper physiological function, and if there is an imbalance, a condition known as oxidative stress can occur that can adversely affect lipids, proteins and DNA, and cause many human diseases[2]. Dietary antioxidants (vitamin C, vitamin E, beta-carotene, etc.) play an important role in neutralizing oxidative stress[3]. However, previous studies have been inconsistent regarding the association between dietary and supplemental antioxidant intake and the risk of ovarian cancer[4,5]. We plan to conduct a study to determine the association between dietary and supplemental antioxidant intake and ovarian cancer risk, and to examine whether this association is modified by factors such as lifestyle.
[1]Webb PM, Jordan SJ. Epidemiology of epithelial ovarian cancer. Best Pract Res Clin Obstet Gynaecol. 2017 May;41:3-14. doi: 10.1016/j.bpobgyn.2016.08.006. Epub 2016 Oct 3. PMID: 27743768.
[2]Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010 Jul;4(8):118-26. doi: 10.4103/0973-7847.70902. PMID: 22228951; PMCID: PMC3249911.
[3]Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci. 2008 Jun;4(2):89-96. PMID: 23675073; PMCID: PMC3614697.
[4]Fleischauer AT, Olson SH, Mignone L, Simonsen N, Caputo TA, Harlap S. Dietary antioxidants, supplements, and risk of epithelial ovarian cancer. Nutr Cancer. 2001;40(2):92-8. doi: 10.1207/S15327914NC402_3. PMID: 11962261.
[5]Koushik A, Wang M, Anderson KE, van den Brandt P, Clendenen TV, Eliassen AH, Freudenheim JL, Genkinger JM, Håkansson N, Marshall JR, McCullough ML, Miller AB, Robien K, Rohan TE, Schairer C, Schouten LJ, Tworoger SS, Wang Y, Wolk A, Zeleniuch-Jacquotte A, Smith-Warner SA. Intake of vitamins A, C, and E and folate and the risk of ovarian cancer in a pooled analysis of 10 cohort studies. Cancer Causes Control. 2015 Sep;26(9):1315-27. doi: 10.1007/s10552-015-0626-0. Epub 2015 Jul 14. PMID: 26169298; PMCID: PMC4907363.
[1]Webb PM, Jordan SJ. Epidemiology of epithelial ovarian cancer. Best Pract Res Clin Obstet Gynaecol. 2017 May;41:3-14. doi: 10.1016/j.bpobgyn.2016.08.006. Epub 2016 Oct 3. PMID: 27743768.
[2]Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010 Jul;4(8):118-26. doi: 10.4103/0973-7847.70902. PMID: 22228951; PMCID: PMC3249911.
[3]Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci. 2008 Jun;4(2):89-96. PMID: 23675073; PMCID: PMC3614697.
[4]Fleischauer AT, Olson SH, Mignone L, Simonsen N, Caputo TA, Harlap S. Dietary antioxidants, supplements, and risk of epithelial ovarian cancer. Nutr Cancer. 2001;40(2):92-8. doi: 10.1207/S15327914NC402_3. PMID: 11962261.
[5]Koushik A, Wang M, Anderson KE, van den Brandt P, Clendenen TV, Eliassen AH, Freudenheim JL, Genkinger JM, Håkansson N, Marshall JR, McCullough ML, Miller AB, Robien K, Rohan TE, Schairer C, Schouten LJ, Tworoger SS, Wang Y, Wolk A, Zeleniuch-Jacquotte A, Smith-Warner SA. Intake of vitamins A, C, and E and folate and the risk of ovarian cancer in a pooled analysis of 10 cohort studies. Cancer Causes Control. 2015 Sep;26(9):1315-27. doi: 10.1007/s10552-015-0626-0. Epub 2015 Jul 14. PMID: 26169298; PMCID: PMC4907363.
Aims
1.Assessment of the association between dietary and supplemental antioxidant intake and ovarian cancer risk.
2.Apply dose-response analysis to examine the relationship between daily intake of antioxidants (dietary and supplemental) and the incidence of ovarian cancer.
3.Using machine learning algorithms to select the best dietary combinations to prevent ovarian cancer.
4.Classification of the population by BMI, smoking status, alcohol consumption, family history, etc. and subgroup analysis of different populations
Collaborators
Chunmei Fan(Department of Laboratorial Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou)
Qingquan Chen, Kang Yang, Xi Zhu, Rongrong Dai(Fujian Medical University, Fuzhou)