Mohamed Rahouma

MD, MS, MSc

Weill Cornell Medicine/ New York Presbyterian Hospital

Assistant Professor in Research in Cardiothoracic surgery

NLST (Learn more about this study)

NLST-1023

Mar 8, 2023

Gender Differences in Lung Cancer Screening in NLST Data: A Comparative Analysis

Introduction: The National Lung Screening Trial (NLST) is a large-scale study that evaluated the efficacy of low-dose computed tomography (LDCT) screening for lung cancer. The study found a significant reduction in lung cancer-related mortality in individuals who underwent LDCT screening. However, there may be gender differences in the utilization and outcomes of lung cancer screening in the NLST data.
Objective: The objective of this study is to analyze gender differences in lung cancer screening utilization, adherence to screening guidelines, and outcomes in the NLST data.
Methodology: This study will be a secondary data analysis of the NLST data. The study will include individuals aged 55 to 74 years who underwent LDCT screening between 2002 and 2009. The study will collect data on demographic characteristics, smoking history, lung cancer screening utilization, and outcomes. The primary outcomes will be the detection rates of lung cancer and the mortality rates due to lung cancer in men and women.
Data Analysis: Descriptive statistics will be used to summarize the data. Chi-square tests will be used to compare differences in lung cancer screening utilization and adherence to screening guidelines between men and women. Multivariate logistic regression analysis will be used to identify factors associated with the detection of lung cancer and the mortality rates due to lung cancer in men and women.
Expected Outcomes: The study is expected to provide insights into gender differences in lung cancer screening in the NLST data. The findings of the study may inform screening guidelines and policies and improve screening strategies for lung cancer in both men and women.
Conclusion: This study will contribute to the body of knowledge on gender differences in lung cancer screening in the NLST data. The findings of the study may have implications for the implementation of LDCT screening programs for lung cancer and may help reduce lung cancer-related mortality in both men and women.