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Principal Investigator
Ling Xiang
The Second Affiliated Hospital of Chongqing Medical University
Position Title
About this CDAS Project
PLCO (Learn more about this study)
Project ID
Initial CDAS Request Approval
Jan 5, 2023
Diabetes risk reduction diet and the risk of head and neck cancer: a large prospective cohort study
Head and neck cancer (HNC) is the seventh most common type of cancer worldwide with high incidence rate and poor prognosis[1]. Research shows that dietary factors are associated with the incidence of HNC[2] Recently, a popular dietary pattern for diabetes prevention named diabetes risk reduction diet (DRRD) was established[3]. Nine dietary variables including cereal fiber, nuts, coffee, whole fruits, the ratio of polyunsaturated to saturated fat, glycemic index (GI), trans-fat, sugar-sweetened beverages (SSBs)/fruit juices, and red and processed meats composed of DRRD[4]. Currently, some prospective studies by large populations suggest that adherence to DRRD can reduce the risk of many cancers, such as lung cancer[5], endometrial cancer[6], breast cancer[4] and pancreatic cancer[7]. However, the impact of DRRD on the risk of HNC remains unclear. Given the high popularity of DRRD and the dismal prognosis of HNC, we performed the study to explore the association between the DRRD and the incidence of HNC.

[1] H. Mehanna, V. Paleri, C. M. West, et al., Head and neck cancer–Part 1: Epidemiology, presentation, and prevention, BMJ (Clinical research ed.), 341 (2010) c4684.
[2] L. L. Eastham, C. M. Howard, P. Balachandran, et al., Eating Green: Shining Light on the Use of Dietary Phytochemicals as a Modern Approach in the Prevention and Treatment of Head and Neck Cancers, Current topics in medicinal chemistry, 18 (2018) 182-191.
[3] T. Wang, M. S. Farvid, J. H. Kang, et al., Diabetes Risk Reduction Diet and Survival after Breast Cancer Diagnosis, Cancer research, 81 (2021) 4155-4162.
[4] S. Ebrahimi Mousavi, A. Bagheri, S. Benisi-Kohansal, et al., Consumption of "Diabetes Risk Reduction Diet" and Odds of Breast Cancer Among Women in a Middle Eastern Country, Frontiers in nutrition, 9 (2022) 744500.
[5] Y. Zhang, G. Zhong, M. Zhu, et al., Association Between Diabetes Risk Reduction Diet and Lung Cancer Risk in 98,159 Participants: Results From a Prospective Study, Frontiers in oncology, 12 (2022) 855101.
[6] G. Esposito, F. Bravi, D. Serraino, et al., Diabetes Risk Reduction Diet and Endometrial Cancer Risk, Nutrients, 13 (2021).
[7] F. Turati, M. Rossi, V. Mattioli, et al., Diabetes risk reduction diet and the risk of pancreatic cancer, European journal of nutrition, 61 (2022) 309-316.

To investigate whether adherence to diabetes risk reduction diet is associated with a lower head and neck cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.


Chaohua Zhang (The Second Affiliated Hospital of Chongqing Medical University)