Skip to Main Content

An official website of the United States government

Diabetes risk reduction diet and the risk of bladder cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Principal Investigator
Name
Yuanhao Chen
Degrees
M.D
Institution
Department of Urology,Beijing Chaoyang Hospital Affiliated To Capital Medical University
Position Title
attending doctor
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-1138
Initial CDAS Request Approval
Jan 3, 2023
Title
Diabetes risk reduction diet and the risk of bladder cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Summary
Type 2 diabetes is a major health issue worldwide and was moderately associated with death from cancers of the liver, pancreas, ovary, colorectum, lung, bladder, and breast[1]. Generally, a healthy diet that can improve insulin sensitivity and reduce inflammation is thought be beneficial to prevent cancer occurrence. Such as the Mediterranean diet, have been shown in some studies to be negatively correlated with the risk of bladder cancer[2]. Previously, Jinnie et al. created a dietary diabetes risk reduction score (DDRRS), which is characterized by high intakes of cereal fiber, polyunsaturated fats, nuts, and coffee; and low amounts of carbohydrates, trans fat, sweets, and red and processed meat [3]. Higher DDRRSs have been associated with lower risks of hepatocellular carcinoma [4] and breast cancer [5]. However, to the best of our knowledge, no epidemiological studies have evaluated the potential association of DDRRS with the risk of bladder cancer. Therefore, our objective is to examine the association between DDRRS and bladder cancer using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial prospective cohort. The PLCO is a well characterized and diverse study population with large number of cancer cases that would provide ample power.
References
[1] Rao Kondapally Seshasai S, Kaptoge S, Thompson A, et al. Diabetes mellitus, fasting glucose, and risk of cause-specific death [published correction appears in N Engl J Med. 2011 Mar 31;364(13):1281]. N Engl J Med. 2011;364(9):829-841.
[2] Witlox WJA, van Osch FHM, Brinkman M, et al. An inverse association between the Mediterranean diet and bladder cancer risk: a pooled analysis of 13 cohort studies. Eur J Nutr. 2020;59(1):287-296
[3] Rhee JJ, Mattei J, Hughes MD, Hu FB, Willett WC. Dietary diabetes risk reduction score, race and ethnicity, and risk of type 2 diabetes in women. Diabetes Care. 2015;38(4):596-603.
[4] Luo X, Sui J, Yang W, et al. Type 2 Diabetes Prevention Diet and Hepatocellular Carcinoma Risk in US Men and Women. Am J Gastroenterol. 2019;114(12):1870-1877.
[5] Kang JH, Peng C, Rhee JJ, et al. Prospective study of a diabetes risk reduction diet and the risk of breast cancer [published online ahead of print, 2020 Oct 6]. Am J Clin Nutr. 2020;nqaa268.
Aims

(1) To clarify the potential association between dietary diabetes risk reduction score and the risk of bladder cancer.
(2) To explore the potential dose-response relationship between dietary diabetes risk reduction score and the risk of bladder cancer.
(3) To evaluate whether DDRRS and related behavioral factors (including nutritional supplements, NSAID use, BMI, physical activity, drug use and sleep condition) interact with the development of bladder cancer.

Collaborators

(1) Zeng Song, Department of Urology, Beijing Chaoyang Hospital Affiliated To Capital Medical University, Beijing, China
(2) Zhang He, Department of Urology, Beijing Chaoyang Hospital Affiliated To Capital Medical University, Beijing, China
(3) Zhang Xin, Department of Urology, Beijing Chaoyang Hospital Affiliated To Capital Medical University, Beijing, China
(4) Hu Xiaopeng, Department of Urology, Beijing Chaoyang Hospital Affiliated To Capital Medical University, Beijing, China

Related Publications