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Principal Investigator
Linglong Peng
The Second Affiliated Hospital of Chongqing Medical University
Position Title
About this CDAS Project
PLCO (Learn more about this study)
Project ID
Initial CDAS Request Approval
Dec 29, 2022
The association between dietary approaches to stop hypertension eating pattern and the risk of lung cancer in the PLCO Cancer Screening Trial
Lung cancer is the second most frequent malignancy with an expected 2.24 million new cases globally in 2020, it is the leading cause of cancer-related mortality, accounting for 18% of all cancer deaths1. Dietary approaches to stop hypertension eating pattern (DASH) was developed from a major hypertension control program in the USA in 1997. It advocates increasing the intake of vegetables, fruits, low-fat dairy products, nuts and legumes, and whole grains, and minimizing the intake of sodium, sweetened beverages, red and processed meats in the diet2. This dietary pattern has been proved to be associated with anti-inflammatory responses and antioxidants3,4, which overlap with the pathogenesis of lung cancer5. However, there is insufficient epidemiological evidence to conclusively link this dietary pattern to lung cancer risk. Thus, we performed the study to explore the association between the DASH diet and the incidence of lung cancer.

1 Sung, H. et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: a cancer journal for clinicians 71, 209-249, doi:10.3322/caac.21660 (2021).
2 Fung, T. T. et al. Adherence to a DASH-style diet and risk of coronary heart disease and stroke in women. Archives of internal medicine 168, 713-720, doi:10.1001/archinte.168.7.713 (2008).
3 Hajjar, M. et al. Association of Dietary Approaches to Stop Hypertension diet and risk of bladder cancer: A case-control study. European journal of cancer care 31, e13664, doi:10.1111/ecc.13664 (2022).
4 Ali Mohsenpour, M. et al. Adherence to Dietary Approaches to Stop Hypertension (DASH)-Style Diet and the Risk of Cancer: A Systematic Review and Meta-Analysis of Cohort Studies. Journal of the American College of Nutrition 38, 513-525, doi:10.1080/07315724.2018.1554460 (2019).
5 Caliri, A. W., Tommasi, S. & Besaratinia, A. Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer. Mutation research. Reviews in mutation research 787, 108365, doi:10.1016/j.mrrev.2021.108365 (2021).

To investigate whether adherence to DASH diet is associated with a lower lung cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.



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