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Principal Investigator
Linglong Peng
The Second Affiliated Hospital of Chongqing Medical University
Position Title
About this CDAS Project
PLCO (Learn more about this study)
Project ID
Initial CDAS Request Approval
Dec 23, 2022
The Sulfur Microbial Diet Is Associated with Increased Risk of Esophageal Cancer in the PLCO Cancer Screening Trial
As the seventh most common and sixth most lethal cancer in the world, esophageal cancer is estimated to have 18,440 new cases and 16,170 cancer deaths in the United States in 2020 [1, 2]. Recently, a newly established dietary pattern, the sulfur microbial diet (SMD) pattern, characterized by high intake of processed meat and liquor, and low intake of other vegetables, legumes, fruit juice and whole grain, has been suggested to increase the colorectal neoplasm risk[3, 4]. However, whether the SMD can increase the risk of esophageal cancer remains to be elucidated. Thus, we performed the study to explore the association between the sulfur microbial diet and the incidence of esophageal cancer.

1. Sung, H., et al., Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: a Cancer Journal For Clinicians, 2021. 71(3): p. 209-249.
2. Siegel, R.L., K.D. Miller, and A. Jemal, Cancer statistics, 2020. CA: a Cancer Journal For Clinicians, 2020. 70(1).
3. Nguyen, L.H., et al., Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men. Gastroenterology, 2020. 158(5): p. 1313-1325.
4. Wang, Y., et al., Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer. JAMA Network Open, 2021. 4(11): p. e2134308.

To investigate the association of the sulfur microbial diet with esophageal cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.