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A systematic evaluation of dietary and behavioral factors associated with endometrial cancer risk and survival

Principal Investigator
Name
Hu Xiaoli
Degrees
M.D., Ph.D., H.X.L.
Institution
The First Affiliated Hospital of Wenzhou Medical University
Position Title
doctor-in-charge
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-1062
Initial CDAS Request Approval
Sep 28, 2022
Title
A systematic evaluation of dietary and behavioral factors associated with endometrial cancer risk and survival
Summary
Endometrial cancer (EC) is a common gynecological malignant tumor and the fifth most common cause of cancer deaths in the United States. Endometrial cancer accounts for nearly 50% of all new gynecologic cancers diagnosed in the United States. Endometrial cancer is typically diagnosed in the sixth and seventh decades of life, when women are postmenopausal and coinciding with a time of decreased bone density. The peak age-specific incidence for endometrial cancer is from age 75 to 79 years. Endometrial cancer has been classified as Type I or II based on tumor histology, disease biology, and patient outcome. Endometrial cancer is a sophisticated disease. Both genetic and environmental factors are considered to play important roles in the carcinogenesis of endometrial cancer. The mechanism of EC still remains contradictory. Further researches are needed to explore potential risk factors and clarify the interaction between them. Therefore, we plan to perform a systematic evaluation of dietary and behavioral factors associated with EC incidence and survival.
The Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial is a randomized, controlled trial enrolling around 155,000 participants between November 1993 and July 2001, providing a comprehensive dataset for EC incidence and mortality analysis. In addition, diet and behavioral information is also available in questionnaires, such as Baseline Questionnaire (BQ), Dietary Questionnaire (DQX) and Supplemental Questionnaire (SQX). Moreover, the bio-samples collected in PLCO also provide a broad base for serum biomarker and genetic data generation for systematic association study.
Aims

1) We plan to systematically evaluate the associations between environmental and behavioral factors (including dietary habits, nutrient supplements, NSAID use, body mass index, physical activity and sleep conditions) and endometrial cancer incidence.
2) If serum biomarkers (e.g., Vitamin D) data of endometrial cancer cases are available, we plan to include the serum biomarkers into the systematic evaluation of the effects of multiple environmental factors with the survival of endometrial cancer patients.
3) If genetic data are available (either targeted array/sequence, genome-wide association study or sequencing data), we plan to investigate the role of genetic variation (as a main effect or interaction with diet and behavioral factors) in relation to endometrial cancer incidence or survival.

Collaborators

Hu yan, Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, People's Republic of China.