Association of Dietary Carrot/Carotene Intakes With Ovarian Cancer Incidence and Mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Principal Investigator
Name
Hu Xiaoli
Degrees
M.D., Ph.D., H.X.L.
Institution
The First Affiliated Hospital of Wenzhou Medical University
Position Title
doctor-in-charge
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1061
Initial CDAS Request Approval
Sep 28, 2022
Title
Association of Dietary Carrot/Carotene Intakes With Ovarian Cancer Incidence and Mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Summary
Ovarian cancer (OC) is the least survivable gynecological malignancy in developed nations. It is associated with significant morbidity and mortality, with 230 000 women being diagnosed, and 150 000 women dying from OC annually.1 Survival at 5 years is less than 50% with survival rates having only increased by 30% since the mid-1970s. Carrot has high amounts of α-carotene and β-carotene and may contribute to cancer prevention. Carotenoid was found to be able to inhibit oxidative damage to DNA at low concentrations and have been hypothesized to be anticancer agents. However, the evidence of dietary carrot/carotene intake's effect on the association with ovarian cancer (OC) risk is conflicted.
Aims
We sought to examine the association of carrot/carotene intake with OC incidence and mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening cohort.
Collaborators
Yu, Jiangtao, Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, People's Republic of China.
Wang yuanqiu, Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, People's Republic of China.
Hu yan, Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, People's Republic of China.