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Principal Investigator
Name
Rachael Stolzenberg-Solomon
Degrees
-
Institution
NCI, DCEG, NEB
Position Title
-
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2007-0001
Initial CDAS Request Approval
Jul 10, 2007
Title
Helicobacter pylori seropositivity as a Risk Factor for Pancreatic Cancer
Summary
Exocrine pancreatic cancer is among the most fatal cancers worldwideand one for which few preventable risk factors have been established(e.g., smoking, diabetes mellitus and obesity). Descriptive epidemiology does indicate the likelihood of important determinants of risk that, when identified, should provide opportunities for prevention. We previously reported a significant 2-fold positive association between Helicobacter pylori (H. pylori) carriage, particularly the cytotoxin-associated gene-A-positive (Cag A+) strain and pancreatic cancer in a nested case control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort(1). This proposed study in PLCO primarily aims to confirm or refute our previous study by determining whether prediagnostic H. pylori and CagA strain seropositivity are associated with pancreatic cancer. We hypothesize that H. pylori and CagA strain seropositivity will be positively associated with pancreatic cancer. We propose to conduct a nested case-control (200 cases and 400 matched controls) study within the PLCO Trial using the T0 serum samples. To our knowledge there have not been published studies confirming or refuting the ATBC findings to date. If our previous study is confirmed in PLCO, it may have important public health implications for the prevention of pancreatic cancer.
Aims

This proposed nested case-control study within the PLCO study cohort aims to confirm or refute our previous study by determining whether H. pylori and CagA strain are associated with pancreatic cancer. The primary aim of this study is: 1. To test the hypothesis that H. pylori and CagA strain seropositivity is associated with pancreatic cancer. We hypothesize that H. pylori and CagA strain seropositivity is positively associated with pancreatic cancer.

Collaborators

Barry Graubard (NCI, DCEG)
Richard Hayes (NCI, DCEG)
Martin Blaser (Departments of Medicine (Infectious Diseases& Immunology) and Microbiology,)
Guillermo Perez-Perez (Departments of Medicine (Infectious Diseases& Immunology) and Microbiology,)
Rachael Stolzenberg-Solomon (NCI, DCEG)