Li Liu

M.D., Ph.D.

Huazhong University of Science and Technology

Professor

PLCO (Learn more about this study)

PLCO-1007

Dec 5, 2022

Environmental exposures, genetic background and their interactions in incidence of cancers and mortality of cancer patients

Environmental and genetic factors have been shown to possess vital impacts on cancer initiation and progression. Lifestyle, as one of the most important environmental exposures, has presented relationship with cancers. Unhealthy lifestyle, such as alcohol consumption, tobacco smoking, and processed meat intake contributes to higher incidence and mortality of cancer. On the other hand, genome-wide association studies have identified abundant susceptibility loci for cancers. Despite a growing recognition of the importance of environment and genetics to cancer, however, relatively little is known about the impact of the gene-environment interactions in incidence of cancers and mortality of cancer patients. As above, we propose to conduct analyses during 36 months investigating how gene-environment interactions impact on incidence of cancers and mortality of cancer patients. With the available genetic and lifestyle data in the PLCO. We plan to identify risk loci and specific lifestyle factors, as well as the gene-environment interactions associated with cancers. This project may help to produce novel intervention measures to reduce cancer burden and improve health and longevity of cancer patients