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Principal Investigator
Name
Chuanwen Fan
Degrees
M.D.,Ph.D.
Institution
WEST CHINA FOURTH HOSPITAL
Position Title
Associate Prof.
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-990
Initial CDAS Request Approval
Jun 22, 2022
Title
The association between vitamins intake and cancer risk and mortality of gastrointestinal cancer
Summary
Gastrointestinal cancers account for 26% of the global cancer incidence burden and 35% of all cancer-related deaths and continue to pose major challenges to public health. There is no doubt that prevention and screening are intended to effectively reduce gastrointestinal cancer incidence and mortality, facilitate early diagnosis and treatment, and thus improve patient survival. There has been increasing epidemiological evidence of the relationship between inadequate intake of vitamins and the gastrointestinal cancer risk, however, it remains controversial. Approximately 30–40% of U.S. adults take multivitamins supplements, and the percentages are even higher among the older population who are a higher incidence of cancer. Although vitamins have important roles in cell metabolism, processing protein, carbohydrates, nerve transmission, energy metabolism, and cell differentiation, which have been proposed to modify the risk of gastrointestinal cancer, they are not always beneficial and can cause harm. Thus, it is of great importance to understand the role of supplementation of vitamins on gastrointestinal cancer development. It is unclear how the dose and the source of vitamin intake (foods versus supplements) are associated with gastrointestinal cancer incidence. Meanwhile, the confounder including lifestyle, diet, smoking, physical activity, and obesity also remains unclear.
Aims

Aim 1: Prospectively evaluate the association between total vitamin intake and gastrointestinal cancer risk and mortality.
Aim 2: To investigate the association between the dose and the source of vitamin intake and gastrointestinal cancer risk and mortality.
Aim 3: To investigate the impact of confounding by health lifestyle, smoking, dietary intake, physical activity, and obesity on vitamin intake in gastrointestinal cancer risk and mortality by performing stratified analysis.

Collaborators

Yanna Shang, College of Public Health, Zhenzhou University.
Zongze Jiang, Department of gastrointestinal surgery, West China School of Public Health and West China Fourth Hospital and Healthy Food Evaluation Research Center, West China-PUMC C.C. Chen Institute of Health, Sichuan University.
Xia Jiang, Department of Nutrition, Food Hygiene and Toxicology, West China School of Public Health and West China Fourth Hospital.
Ben Zhang, Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University