Chuanwen Fan

M.D.,Ph.D.

WEST CHINA FOURTH HOSPITAL

Associate Prof.

PLCO (Learn more about this study)

PLCO-990

Jun 22, 2022

The association between vitamins intake and cancer risk and mortality of gastrointestinal cancer

Gastrointestinal cancers account for 26% of the global cancer incidence burden and 35% of all cancer-related deaths and continue to pose major challenges to public health. There is no doubt that prevention and screening are intended to effectively reduce gastrointestinal cancer incidence and mortality, facilitate early diagnosis and treatment, and thus improve patient survival. There has been increasing epidemiological evidence of the relationship between inadequate intake of vitamins and the gastrointestinal cancer risk, however, it remains controversial. Approximately 30–40% of U.S. adults take multivitamins supplements, and the percentages are even higher among the older population who are a higher incidence of cancer. Although vitamins have important roles in cell metabolism, processing protein, carbohydrates, nerve transmission, energy metabolism, and cell differentiation, which have been proposed to modify the risk of gastrointestinal cancer, they are not always beneficial and can cause harm. Thus, it is of great importance to understand the role of supplementation of vitamins on gastrointestinal cancer development. It is unclear how the dose and the source of vitamin intake (foods versus supplements) are associated with gastrointestinal cancer incidence. Meanwhile, the confounder including lifestyle, diet, smoking, physical activity, and obesity also remains unclear.