The association between dietary beta-carotene intake and behavioral risk factors and invasive cancer risk
Principal Investigator
Name
Ai Zhao
Degrees
Ph.D
Institution
Vanke School of Public Health, Tsinghua University
Position Title
Associate Professor
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-974
Initial CDAS Request Approval
May 9, 2022
Title
The association between dietary beta-carotene intake and behavioral risk factors and invasive cancer risk
Summary
Antioxidants have anti-inflammatory activities and were found to lower the all-cause mortality in general healthy population in observational studies. However, the associations with incidence and mortality of site-specific cancers were inconsistent. Beta-carotene is widely available in plants, and it helps prevent oxidative damage and balance the free radicals which may cause the development of various types of cancers. In addition, several lifestyle factors like smoking status and alcohol consumption were found to have modification effects on antioxidants intake and total cancer rates. Therefore, we plan to perform a longitudinal study examining the association between dietary beta-carotene intake and invasive cancer risk, and examine whether the association would be modified by lifestyle factors.
Aims
We aim to evaluate the beta-carotene intake from diet and supplements and cancer risk using data from Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial. The interested exposures include dietary intake of antioxidants, daily energy consumption, cigarette smoking status, alcohol consumption, body mass index, physical activity, medication use, and immune biomarkers (in Lung 2nd).
Collaborators
Ai Zhao, Vanke School of Public Health, Tsinghua University, Beijing, China
Xiaona Na, Vanke School of Public Health, Tsinghua University, Beijing, China
Jiaqi Yang, Vanke School of Public Health, Tsinghua University, Beijing, China
Related Publications
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Association between Dietary and Supplemental Antioxidants Intake and Lung Cancer Risk: Evidence from a Cancer Screening Trial
Jiaqi Yang 1,2ORCID,Sicheng Qian 1,3,Xiaona Na 1 and Ai Zhao 1,
Antiox. 2023 Jan 31; Volume 12 (Issue 2): Pages 338 PUBMED