The purpose of our application for PLCO database is to make fully integrated use of the existing database of our research group as well as PLCO database to conduct research on the relationship between tumors and diet (diet including alcohol intake, fruits and vegetables intake to estimate dietary fibre, etc). However, Mendelian randomization study has been used widely to address the causal relation of risk factors with diseases considering that the genotypes of single nucleotide polymorphism were less likely to be affected by confounding factors and reverse causation. Alcohol drinking as one of the major environmental risk factors of cancers may in concert with genetic factors affecting the development and progression of cancers. We plan to conduct a genome-wide interaction analysis between SNPs and alcohol drinking status and the volume of dietary fibre intake. We will use PLCO data as discovery dataset, the significant factors from the discovery analysis will be used to build tumor polygenic risk prediction models, then tested in the UK Biobank data and our own Chinese groups. We hope to build a reasonable tumor prediction model and screen as many high-risk groups as possible.

Miao Xiaoping, School of Health Public Wuhan University.
Tian Jianbo, School of Health Public Wuhan University.
Zhu Ying, School of Health Public Wuhan University.