Study
PLCO
(Learn more about this study)
Project ID
PLCO-899
Initial CDAS Request Approval
Jan 18, 2022
Title
Association of dietary carrot intake with colorectal cancer incidence and mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Summary
Colorectal cancer (CRC) is the third most common cause of cancer death in both men and women in the United States and ranks second when men and women are combined. However, more than one-half of all cases and deaths are attributable to modifiable risk factors, such as smoking, an unhealthy diet, high alcohol consumption, physical inactivity, and excess body weight, and thus potentially preventable. Carrot has high amounts of α-carotene and β-carotene and may contribute to cancer prevention. Carotenoid was found to be able to inhibit oxidative damage to DNA at low concentrations and have been hypothesized to be anticancer agents. It has been shown that β-carotene upregulates the PPAR-γ-mediated expression of antioxidant enzymes. Several epidemiological studies have reported an inverse or null association between carrot intake and cancer risk in bladder cancer, prostate cancer, breast cancer, urothelial cancer, and gastric cancer. To our knowledge, only one prospective cohort in Danes has investigated the association between dietary carrot intake and risk of colorectal cancer, which found that Self-reported intake of raw carrots at a baseline of 2–4 carrots or more each week (>32 g/day) was associated with a 17% decrease in risk of CRC with a mean follow-up of >18 years, compared to individuals with no intake of raw carrots even after extensive model adjustments (HR 0.83 CI 95% 0.71; 0.98). An intake below 2–4 carrots each week (<32 g/day) was not significantly associated with a reduced risk of CRC (HR 0.93 CI 95% 0.82; 1.06). However, whether the results would be stable when validated in the US population.
Aims
(1) To examine the association of dietary carrot intake (total Carrot, α-carotene, and β-carotene) and colorectal cancer incidence.
(2) To examine the association of dietary carrot intake (total Carrot, α-carotene, and β-carotene) and colorectal cancer mortality.
(3) To examine the potential dose-response relationship between dietary carrot intake (total Carrot, α-carotene, and β-carotene) and colorectal cancer incidence and mortality.
Collaborators
(1)Chuanwen Fan, affiliation: Department of Gastrointestinal Surgery, Bariatric and Metabolic Surgery, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China
(2) Feiwu Long, affiliation: Department of Gastrointestinal Surgery, Bariatric and Metabolic Surgery, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China
