Endometrial thickness and risk of hormone-related malignancies
Principal Investigator
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
2012-0352
Initial CDAS Request Approval
Aug 30, 2012
Title
Endometrial thickness and risk of hormone-related malignancies
Summary
Endometrial thickness, as measured by transvaginal ultrasound, is associated with risk factors thought to reflect estrogen exposure. Our primary objective is to examine the risk of sex hormone-related cancers (endometrial, breast, colorectal and ovarian) in relation to endometrial thickness as measured in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial. Female participants enrolled at the Pittsburgh PLCO Center with a known baseline endometrial thickness measurement will be included (N=1,271). Cox proportional hazards regression will be used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between endometrial thickness, cancer incidence and cancer-specific mortality. This investigation will add to the growing body of knowledge regarding the epidemiology of the selected cancers, with the potential to identify women requiring increased surveillance for early cancer detection.
Aims
1.) To evaluate the association between endometrial thickness and endometrial, breast, colorectal and ovarian cancer risk. We hypothesize that increased endometrial thickness will be associated with increased risks of endometrial, breast, colorectal and ovarian cancer. 2.) To evaluate the association between endometrial thickness, cancer-specific mortality (endometrial, breast, colorectal and ovarian) and all-cause mortality.
Collaborators
Amanda Black (DCEG, Office of the Director)
Louise Brinton (Hormonal and Reproductive Epidemiology Branch)
Joel Weissfeld (University of Pittsburgh)
Mark Sherman (Hormonal and Reproductive Epidemiology Branch)