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Principal Investigator
Name
Emily Vogtmann
Degrees
Ph.D., M.P.H.
Institution
National Cancer Institute
Position Title
Investigator
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2022-0007
Initial CDAS Request Approval
Aug 2, 2022
Title
Association of the oral microbiome with breast cancer incidence
Summary
There are indications that the oral microbiome may be related to breast cancer incidence, but the previous literature either used a proxy for the oral microbiome (i.e., oral health or periodontal disease) or were case-control studies. Therefore, we propose to measure the prediagnostic oral microbiome from prospectively ascertained breast cancer cases and matched controls in PLCO to investigate the role of oral microbiome in breast cancer development. If the oral microbiome is found to be associated with breast cancer incidence, the microbiome could represent a modifiable target for breast cancer prevention.
Aims

Using previously extracted oral wash specimens in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, we aim to: Prospectively evaluate the associations between the oral microbiome and breast cancer incidence within 1,386 incident breast cancers and 1,386 incidence-density matched controls

Collaborators

Emily Vogtmann (National Cancer Institute)
Jianxin Shi (National Cancer Institute)
Mitch Gail (National Cancer Institute)
Wen-Yi Huang (National Cancer Institute)
Gretchen Gierach (National Cancer Institute)
Neal Freedman (National Cancer Institute)
Rashmi Sinha (National Cancer Institute)