Evaluation of the performance of Asia Pacific Colorectal Screening (APCS) score for colorectal neoplasia risk stratification in the PLCO population
Principal Investigator
Name
Zhangyan Lyu
Degrees
Ph.D.
Institution
Tianjin Medical University Cancer Institute and Hospital
Position Title
Research Associate
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-848
Initial CDAS Request Approval
Nov 3, 2021
Title
Evaluation of the performance of Asia Pacific Colorectal Screening (APCS) score for colorectal neoplasia risk stratification in the PLCO population
Summary
Incorporating simple demographic factors to screen appropriately at-risk populations for colorectal cancer (CRC) screening may improve the efficiency of health care utilization by reducing futile colonoscopies and promoting adherence for colonoscopy. The Asia Pacific Working Group on CRC proposed a simple risk score which was named Asia Pacific Colorectal Screening (APCS) score comprising demographic risk factors: age, sex, family history of CRC, and smoking status. Subsequently, researchers from Asia countries including Thailand, China, Japan, South Korea, and Vietnam had validated that the APCS score could be a cost-effective tool for large CRC screening cohorts. Moreover, the APCS score was also developed constantly by considering new risk factors of the model or combining fecal immunochemical tests in CRC screening.
As for Western populations, to date, only two studies evaluated the efficiency of APCS score in Australians and German individuals. However, only one of them explored other factors beyond the APCS factors but in outpatients not in the screening population. Moreover, the correlation between APCS score and mortality of CRC in a large screening population is yet to be tested.
The PLCO is a well-characterized and diverse study population with a large number of colorectal advanced neoplasia cases that would provide ample power. In this study, we primarily aim to evaluate the APCS score on the incidence of colorectal advanced neoplasia and explore the correlation between APCS score and mortality of CRC by using the PLCO cohort dataset. The findings may provide both new evidence for the improvement of APCS score and new clue for CRC screening in Western countries.
As for Western populations, to date, only two studies evaluated the efficiency of APCS score in Australians and German individuals. However, only one of them explored other factors beyond the APCS factors but in outpatients not in the screening population. Moreover, the correlation between APCS score and mortality of CRC in a large screening population is yet to be tested.
The PLCO is a well-characterized and diverse study population with a large number of colorectal advanced neoplasia cases that would provide ample power. In this study, we primarily aim to evaluate the APCS score on the incidence of colorectal advanced neoplasia and explore the correlation between APCS score and mortality of CRC by using the PLCO cohort dataset. The findings may provide both new evidence for the improvement of APCS score and new clue for CRC screening in Western countries.
Aims
The PLCO data are needed to conduct the following specific aims:
1) To evaluate the discriminatory performance of the APCS score for the risk of colorectal neoplasia occurrence and CRC-related deaths.
2) To systematically examine the impact of other factors beyond APCS score to update the present APCS score in a Western population.
Collaborators
None.