Validation of Linkage-Identified Prostate Cancer Susceptibility Loci
Principal Investigator
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
2011-0277
Initial CDAS Request Approval
Feb 2, 2012
Title
Validation of Linkage-Identified Prostate Cancer Susceptibility Loci
Summary
Genome-wide association studies and linkage analyses have both provided evidence for the existence of prostate cancer susceptibility loci. However, GWAS loci generally do not intersect with the loci identified by family-based studies. Our proposal is to evaluate the evidence for association for linkage-identified loci using GWAS data. This proposal will provide evidence for or against previously identified prostate cancer loci from linkage studies using data from GWAS evaluations.
Aims
Specific Aim 1: To validate the identification of prostate cancer loci from linkage/family studies using GWAS data.
Collaborators
Bao-Li Chang (University of Pennsylvania)
Timothy Rebbeck (University of Pennsylvania)