Skip to Main Content

An official website of the United States government

Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at OPM.gov.

Validation of Linkage-Identified Prostate Cancer Susceptibility Loci

Principal Investigator
Name
Timothy Rebbeck
Institution
University of Pennsylvania
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2011-0277
Initial CDAS Request Approval
Feb 2, 2012
Title
Validation of Linkage-Identified Prostate Cancer Susceptibility Loci
Summary
Genome-wide association studies and linkage analyses have both provided evidence for the existence of prostate cancer susceptibility loci. However, GWAS loci generally do not intersect with the loci identified by family-based studies. Our proposal is to evaluate the evidence for association for linkage-identified loci using GWAS data. This proposal will provide evidence for or against previously identified prostate cancer loci from linkage studies using data from GWAS evaluations.
Aims

Specific Aim 1: To validate the identification of prostate cancer loci from linkage/family studies using GWAS data.

Collaborators

Bao-Li Chang (University of Pennsylvania)
Timothy Rebbeck (University of Pennsylvania)