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Diet and glioma: the Harvard Pooling Project

Principal Investigator
Name
Cari Kitahara
Institution
NCI, DCEG, NEB
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2011-0252
Initial CDAS Request Approval
Nov 28, 2011
Title
Diet and glioma: the Harvard Pooling Project
Summary
We will expand the focus of the Pooling Project of Prospective Studies of Diet and Cancer (Pooling Project), an international consortium of cohort studies, to examine associations between dietary factors and risk of incident gliomas. We propose to pool the primary data from 24 prospective studies, including PLCO. Together, these cohorts provide data on 2,348,557 individuals followed between 6-22 years. Expansion of the Pooling Project to this rare cancer site takes advantage of the statistical power obtained from combining data from multiple studies because most individual cohort studies in the project have few glioma cases and thus have limited ability to examine associations with dietary factors. The dietary factors of interest include vitamins C, D, and E, retinol, carotenoids, processed meat, fish and marine n3 fatty acids, total fat, fruit and vegetables, alcohol, and folate.
Aims

We will evaluate the following hypotheses for gliomas in 24 studies: 1. Vitamin D intake is inversely associated with glioma risk. High intake of retinol attenuates the decreased risk with vitamin D. 2. Intakes of vitamins C and E and carotenoids are inversely associated with the risk of gliomas. 3. Processed meat consumption is positively associated with glioma risk. Vitamin C and E intakes and multivitamin use modify the association between processed meat consumption and glioma risk such that processed meat consumption is associated with a higher risk of gliomas among individuals with low vitamin C intake, low vitamin E intake, and who do not use multivitamins. 4. Fish and marine n3 fatty acid intakes are inversely associated with the risk of gliomas; however total fat intake is not associated with the risk of gliomas. 5. Fruit and vegetable consumption is inversely associated with the risk of gliomas. 6. Alcohol intake is positively associated with glioma risk, particularly among individuals with low intake of folate.

Collaborators

Cari Kitahara (National Cancer Institute, Division of Cancer Epidemiology and Genetics)
Preetha Rajaraman (National Cancer Institute, Division of Cancer Epidemiology and Genetics)
Regina Ziegler (National Cancer Institute, Division of Cancer Epidemiology and Genetics)