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Risk factors for second cancers among colorectal cancer survivors in a cohort consortium

Principal Investigator
Name
Todd Gibson
Institution
NCI, DCEG, REB
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2011-0235
Initial CDAS Request Approval
Nov 3, 2011
Title
Risk factors for second cancers among colorectal cancer survivors in a cohort consortium
Summary
Most colorectal cancer patients are now diagnosed with localized or regional disease and have good relative survival, so understanding the subsequent cancer risk of this population is increasingly important. Incidence patterns suggest important roles for shared dietary, lifestyle, and genetic risk factors, but registry studies lack data on these factors, and the etiology of second cancers after CRC is poorly understood. The aims of the proposed research include 1) evaluating the utility of prospective cohort studies to examine risk factors for second primary cancers, and 2) examining associations of overweight/obesity and aspirin/NSAID use with risk of second primary cancers among colorectal cancer survivors. The proposed studies are important as proof-of-principle studies for use of prospective cohorts in second cancer research and will also provide opportunities to gain important knowledge on the etiology of cancer among colorectal cancer survivors.
Aims

1. To evaluate the utility of prospective cohort studies to examine risk factors for second primary cancers, particularly factors for which data is available from post-baseline follow-up assessments. 2. To examine overweight/obesity as a risk factor for subsequent primary cancers overall, for obesity-related cancers, and for specific cancers such as metachronous colorectal, breast, endometrial, esophageal, liver, prostate, and kidney, among colorectal cancer survivors. 3. To examine the association between aspirin/NSAID use and risk of subsequent primary cancers, overall and particularly for metachronous colorectal, breast, ovarian, prostate, stomach, and esophageal, among colorectal cancer survivors. 4. To assess changes among colorectal cancer survivors in body mass index and/or use of aspirin/NSAIDS between baseline questionnaires and follow-up questionnaires in each cohort and to assess the association between changes over time and subsequent cancer risk. 5. To assess whether associations between overweight/obesity or aspirin/NSAID use and a second primary cancer among colorectal cancer survivors differ from associations between the same risk factors and a first primary cancer in the cohort.

Collaborators

Demetrius Albanes (NCI-DCEG)
Amanda Black (NCI-DCEG)
Joseph Fraumeni Jr. (NCI-DCEG)
Josh Sampson (NCI-DCEG)
Lindsay Morton (NCI-DCEG)
Yikyung Park (NCI-DCEG)
Rochelle Curtis (NCI-DCEG)
Kim Robien (University of Minnesota)
Sara Schonfeld (NCI-DCEG)
Meredith Shiels (NCI - DCEG)