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Risk factors for second cancers among survivors of tobacco- and alcohol-related cancers

Principal Investigator
Name
Meredith Shiels
Institution
NCI, DCEG, IIB
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2011-0234
Initial CDAS Request Approval
Nov 3, 2011
Title
Risk factors for second cancers among survivors of tobacco- and alcohol-related cancers
Summary
Tobacco- and alcohol-related cancers account for a substantial proportion of the burden of multiple primary malignancies. In data from the Surveillance, Epidemiology and End Results (SEER) program from 1973-2000, tobacco and alcohol-related second cancers comprised more than 35% of all subsequent cancers (1). Though not well studied, the risk of developing a second primary cancer is likely increased by the continued use of tobacco and alcohol after first cancer diagnosis. As registry-based studies provide the majority of the information on second cancer risk, it has been difficult to assess the associations between individual-level risk factors and cancer in cancer survivors. In order to identify risk factors for second primary malignancies occurring after a primary lung, bladder, kidney or head and neck cancer, we propose pooling data from PLCO with several other cohorts. First, we will estimate the associations between tobacco and alcohol use and second cancer risk among survivors of primary bladder, kidney, lung and head and neck cancers. Next, we will estimate whether the associations between tobacco and alcohol and first primary bladder, kidney, lung or head and neck cancer are the same as the associations between tobacco and alcohol use and second primary bladder, kidney, lung or head and neck cancer. The results from this study will provide clinically relevant and novel information on second cancer risk in survivors of first primary tobacco- and alcohol-related cancers. Further, it will serve as a proof-of-principle for future studies of second cancers using pooled cohort studies.
Aims

Specific Aim 1: To estimate the association between baseline tobacco and alcohol use and subsequent cancer risk in participants with bladder, kidney, lung and head and neck cancers. Specific Aim 2: To assess changes in tobacco and alcohol use between baseline questionnaire and follow-up questionnaires in each cohort and to assess the association between these changes and subsequent cancers after diagnosis with bladder, kidney, lung or head and neck cancers. To quantify the proportion of participants in each cohort that change status and frequency of tobacco and alcohol use after the baseline measures. To relate changes over time in tobacco and alcohol use to diagnosis of first primary cancer diagnosis (bladder, kidney, lung, and head and neck). To assess whether changes in tobacco and alcohol consumption alter the risk of subsequent cancer, compared with baseline measures. Specific Aim 3: To estimate whether the associations between tobacco and alcohol use and a first primary bladder, kidney, lung or head and neck cancer are the same as the associations between tobacco and alcohol use and a second primary bladder, kidney, lung or head and neck cancer.

Collaborators

Demetrius Albanes (DCEG)
Amanda Black (DCEG)
Neil Caporaso (DCEG)
Neal Freedman (DCEG)
Todd Gibson (DCEG)
Lindsay Morton (DCEG)
Rochelle Curtis (DCEG)
Kim Robien (University of Minnesota)
Josh Sampson (DCEG)
Joanne Watters (DCCPS)

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