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Principal Investigator
Name
Cari Kitahara
Institution
NCI, DCEG, NEB
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2011-0229
Initial CDAS Request Approval
Sep 22, 2011
Title
Association between body mass index and mortality in non-Hispanic blacks
Summary
Two large consortia have recently performed pooled analyses to assess the association between BMI and mortality (1,2). The results of these two studies, including over 2 million subjects, both concluded that overweight and obesity are associated with increased all-cause mortality. However, the Prospective Studies Collaboration (including 900,000 subjects from Europe and North America) did not stratify by race and the National Cancer Institute Consortium only include white, non-Hispanic subjects (1.46 million). As such, there is little information on the association between BMI and all-cause mortality in African Americans. We aim to examine the association between BMI and all-cause mortality in African Americans in the PLCO cohort. We plan to additionally investigate the causes of mortality using the following broad categories: cancer, cardiovascular, and other. We understand that information related to colon and lung cancer will not be released until the publication of the final manuscripts. References 1. Prospective Studies Collaboration, Whitlock G, Lewington S, Sherliker P, Clarke R, et al. Body-mass index and cause-specific mortality in 900,000 adults: collaborative analyses of 57 prospective studies. Lancet 2009;373:1083-96 2. Berrington de Gonzalez A, Hartge P, Cerhan JR, Flint AJ, Hannan L, et al. Body-mass index and mortality among 1.46 million white adults. N Engl J Med 2010;363(23):2211-9.
Aims

1. Examine the association between BMI (categorically and continuously) and all-cause mortality among non-Hispanic blacks in PLCO (n=7,831). 2. Examine the association between BMI and cause-specific mortality (cancer, cardiovascular disease, and "other") among non-Hispanic blacks in PLCO. 3. Compare the association between BMI and mortality among non-Hispanic blacks and non-Hispanic whites in PLCO.

Collaborators

Amy Berrington de Gonzalez (Division of Cancer Epidemiology and Genetics)
Ann Hsing (Division of Cancer Epidemiology and Genetics)

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