Invasive Procedures and Associated Complications Following Initial Lung Cancer Screening in a National Cohort of Veterans.
Principal Investigator
Name
Eduardo Nunez
Degrees
MD
Institution
Boston University
Position Title
Pulmonary and Critical Care Fellow
Email
About this CDAS Project
Study
NLST
(Learn more about this study)
Project ID
NLST-822
Initial CDAS Request Approval
Jul 26, 2021
Title
Invasive Procedures and Associated Complications Following Initial Lung Cancer Screening in a National Cohort of Veterans.
Summary
RATIONALE:
Lung cancer screening (LCS) has the potential to reduce lung cancer mortality by 20%. LCS can also have downstream harms, including physical complications of invasive procedures. Our objective was to characterize the frequency of complications from invasive procedures after undergoing screening and to identify factors associated with complications.
We are working on a retrospective cohort analysis of Veterans who underwent LCS in any Veterans Health Administration (VA) facility between 2013-2019. We used administrative data from VA’s Corporate Data Warehouse to identify Veterans who had invasive procedures within 10 months of LCS. The primary outcome was presence of a complication within 10 days after an invasive procedure based on International Classification of Disease codes. We conducted hierarchical mixed effects logistic regression analyses, including both patient- and facility-level variables, to determine factors associated with complications from an invasive procedure.
We would like access to the NLST data so that we can compare findings from our work regarding rates of procedures and complications through each of the rounds of the screening to our findings and so that we are better able to comment about our differences in the discussion section.
Lung cancer screening (LCS) has the potential to reduce lung cancer mortality by 20%. LCS can also have downstream harms, including physical complications of invasive procedures. Our objective was to characterize the frequency of complications from invasive procedures after undergoing screening and to identify factors associated with complications.
We are working on a retrospective cohort analysis of Veterans who underwent LCS in any Veterans Health Administration (VA) facility between 2013-2019. We used administrative data from VA’s Corporate Data Warehouse to identify Veterans who had invasive procedures within 10 months of LCS. The primary outcome was presence of a complication within 10 days after an invasive procedure based on International Classification of Disease codes. We conducted hierarchical mixed effects logistic regression analyses, including both patient- and facility-level variables, to determine factors associated with complications from an invasive procedure.
We would like access to the NLST data so that we can compare findings from our work regarding rates of procedures and complications through each of the rounds of the screening to our findings and so that we are better able to comment about our differences in the discussion section.
Aims
1) Quantify rates of downstream procedures from lung cancer screening in a national cohort of Veterans
2) Identify factors associated with development of complications
3) Compare our findings from real-world populations to those found in the National Lung Screening Trial to help better guide shared decision making conversations with patients and update risk calculators.
Collaborators
Renda Soylemez Wiener, MD, MS