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A systematic evaluation of dietary, hormonal factors, medical history, and medication use and behavioral factors associated with pancreatic cancer risk

Principal Investigator
Name
Xiaoya Wang
Degrees
PhD. Candidate
Institution
Nanchong Central Hospital,The Second Clinical College, North Sichuan Medical College
Position Title
research fellow
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-815
Initial CDAS Request Approval
Jul 26, 2021
Title
A systematic evaluation of dietary, hormonal factors, medical history, and medication use and behavioral factors associated with pancreatic cancer risk
Summary
Pancreatic cancer is the fourth most common cause of cancer mortality and ranks 10th in the incidence of all cancers in the United States. The etiology is largely unknown. To date, modifiable risk factors included smoking, obesity, genetics, diabetes, and diet, however, modifiable risk factors are supported by various levels of evidence.
This study is suitable for the PLCO cohort because detailed information on demographic characteristics, anthropometric measures, family history of cancer, reproductive factors, smoking history, diet, personal medical history was collected.
Aims

In this study, the outcome is pancreatic cancer incidence. The exposure of interest would include body mass index, physical activity, coffee, cigarette smoking, alcohol intake, and vegetables and fruits consumption, other diets, exogenous hormone use, reproductive factors, and menstrual factors. Cox proportional-hazard regression was used to estimate the hazards ratios, which adjusted for sex, race/ethnicity, education, marital status, and others if the data are available.

Collaborators

Qingbao Xu, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College;
Chuan Shao, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College;
Hui Tang, Nanchong Central Hospital,The Second Clinical College, North Sichuan Medical College;
Jiaquan He, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College;