Smoking and Colorectal Cancer
Principal Investigator
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
2011-0204
Initial CDAS Request Approval
Aug 31, 2011
Title
Smoking and Colorectal Cancer
Summary
While studies consistently have reported an association between smoking status (ever vs. never) and pack-year with risk of colorectal cancer (CRC), results are less clear for recency of smoking and time since quite smoking and CRC risk. Recently two meta-analyses (1, 2) consistently showed weaker associations for current smokers than former smokers, particularly in women. These results may indicate interactions with BMI or effects on hormone levels. Furthermore, we found that studies on time since quitting and CRC risk are limited and the results are inconsistent. Therefore, we propose to perform a pooled analysis in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) to conduct a detailed assessment of the association between smoking and CRC risk and the interaction effects between smoking and other risk factors related to CRC risk.
Aims
(1) To evaluate the association between cigarette smoking and risk of CRC, particular interested in the association between time since quite smoking and risk of CRC and whether this association could be modified by factors such as age of initiation, daily cigarette smoking, and pack-years. (2) To examine the interaction effects of smoking and other factors related to CRC risk such as vegetables and fruits intake, alcohol intake, dietary fibre, BMI, and HRT. (3) To build a risk model to identify which of the smoking variables contribute significantly to the risk of CRC
Collaborators
Amanda Phipps (Fred Hutchinson Cancer Research Cencer)
Carolyn Hutter (Fred Hutchinson Cancer Research Cencer)
Jian Gong (Fred Hutchinson Cancer Research Cencer)