Place of birth, race-ethnicity and the risk of colorectal neoplasia
Principal Investigator
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
2011-0067
Initial CDAS Request Approval
Jun 9, 2011
Title
Place of birth, race-ethnicity and the risk of colorectal neoplasia
Summary
Based on the studies of Japanese immigrants in Hawaii over three decades ago which suggested that Japanese immigrants eventually acquired a risk of colon cancer comparable to that of US-born Caucasians, it is widely believed that adoption of a "western diet" results in a risk of colon cancer similar to that of persons born in the US. However, nationally representative data suggest a lower risk of colonic neoplasia among Asians and Hispanics when compared to Caucasians, but an elevated risk for blacks. A lot of changes in population dynamics has occurred in the US since these studies were published and no recent study has compared the risk of colorectal neoplasia between foreign-born persons with US-born individuals. Furthermore, no previous study has evaluated the risk of colorectal neoplasia among immigrant populations and their US-born counterparts of the same race-ethnicity.
Aims
1. To compare the yield of neoplasia detection of screening flexible sigmoidoscopy between PLCO participants born outside the United States with those born in the US. 2. To compare the yield of colorectal neoplasia by race-ethnicity comparing PLCO participants born outside the United States with those born in the US.
Related Publications
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Occurrence of Distal Colorectal Neoplasia Among Whites and Blacks Following Negative Flexible Sigmoidoscopy: An Analysis of PLCO Trial.
Laiyemo AO, Doubeni C, Pinsky PF, Doria-Rose VP, Bresalier R, Hickey T, Riley T, Church TR, Weissfeld J, Schoen RE, Marcus PM, Prorok PC
J Gen Intern Med. 2015 Oct; Volume 30 (Issue 10): Pages 1447-53 PUBMED