NOS Genetics

Principal Investigator

Name
Daehee Kang

Institution
NCI, DCEG, OEEB

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
2006-0005

Initial CDAS Request Approval
Jul 1, 2006

Title
NOS Genetics

Summary
This study is conducted to evaluate the potential role of selected single nucleotide polymorphisms (SNPs) of NOS2 and NOS3 with large number of subjects in prostate cancer development with a nested case-control design in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial.

Aims

To study the association between selected genetic polymorphisms of NOS and prostate cancer, especially advanced prostate cancer To evaluate the interactive effects of genetic polymorphisms of NOS and environmental exposure on prostate cancer development.

Collaborators

Ed Glemann (Georgetown University)
Richard Hayes (Division of Cancer Epidemiology and Genetics)
Wen-Yi Huang (Division of Cancer Epidemiology and Genetics)

Related Publications

• Lack of association of transforming growth factor-beta1 polymorphisms and haplotypes with prostate cancer risk in the prostate, lung, colorectal, and ovarian trial.
  Kang D, Lee KM, Park SK, Berndt SI, Reding D, Chatterjee N, Welch R, Chanock S, Huang WY, Hayes RB
  Cancer Epidemiol. Biomarkers Prev. 2007 Jun; Volume 16 (Issue 6): Pages 1303-5 PUBMED