Plant-based diet and the risk of pancreatic cancer in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
Principal Investigator
Name
Guo-Chao Zhong
Degrees
Ph.D.
Institution
The Second Affiliated Hospital of Chongqing Medical University
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-755
Initial CDAS Request Approval
Mar 30, 2021
Title
Plant-based diet and the risk of pancreatic cancer in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
Summary
Pancreatic cancer is the fourth leading cause of cancer-related mortality in the US population, and its prognosis is still dismal. Hence, identifying modifiable risk factors is important for decreasing the burden of this disease. The well-established risk factors for pancreatic cancer include type 2 diabetes, cigarette smoking, and obesity (1). Interestingly, dietary habits have been also indicated to play an important role in the initiation and development pancreatic cancer (2).
Plant-based diet has been associated with a series of health outcomes, including metabolic syndrome (3) and type 2 diabetes (4). However, to our knowledge, no large prospective cohort study has accurately evaluated the potential association between plant-based diet and the risk of pancreatic cancer. Hence, we sought to examine this potential association in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.
References:
1. Tsai HJ, Chang JS. Environmental Risk Factors of Pancreatic Cancer. J Clin Med. 2019;8(9).
2. Casari I, Falasca M. Diet and Pancreatic Cancer Prevention. Cancers (Basel). 2015;7(4):2309-17.
3. Kim H, Lee K, Rebholz CM, Kim J. Plant-based diets and incident metabolic syndrome: Results from a South Korean prospective cohort study. PLoS Med. 2020;17(11):e1003371.
4. Satija A, Bhupathiraju SN, Rimm EB, et al. Plant-Based Dietary Patterns and Incidence of Type 2 Diabetes in US Men and Women: Results from Three Prospective Cohort Studies. PLoS Med. 2016;13(6):e1002039.
Plant-based diet has been associated with a series of health outcomes, including metabolic syndrome (3) and type 2 diabetes (4). However, to our knowledge, no large prospective cohort study has accurately evaluated the potential association between plant-based diet and the risk of pancreatic cancer. Hence, we sought to examine this potential association in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.
References:
1. Tsai HJ, Chang JS. Environmental Risk Factors of Pancreatic Cancer. J Clin Med. 2019;8(9).
2. Casari I, Falasca M. Diet and Pancreatic Cancer Prevention. Cancers (Basel). 2015;7(4):2309-17.
3. Kim H, Lee K, Rebholz CM, Kim J. Plant-based diets and incident metabolic syndrome: Results from a South Korean prospective cohort study. PLoS Med. 2020;17(11):e1003371.
4. Satija A, Bhupathiraju SN, Rimm EB, et al. Plant-Based Dietary Patterns and Incidence of Type 2 Diabetes in US Men and Women: Results from Three Prospective Cohort Studies. PLoS Med. 2016;13(6):e1002039.
Aims
To examine this potential association between plant-based diet and the risk of pancreatic cancer in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.
Collaborators
(1) Jing-Jing Wu, Department of Nutrition and Food Hygiene, School of Public Health and Management, Chongqing Medical University, Chongqing, China
(2) Yang Peng, Department of Geriatrics, the Fifth People’s Hospital of Chengdu, Chengdu, China
(3) Peng-Fei Yang, Department of Nephrology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Related Publications
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Plant-based diets and the risk of pancreatic cancer: a large prospective multicenter study.
Zhong GC, Li Z, You AJ, Zhu Q, Wang CR, Yang PF
Am J Clin Nutr. 2023 Feb; Volume 117 (Issue 2): Pages 235-242 PUBMED