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Identification and Quantification of Cardiac Calcium and cardiovascular Risk Stratification

Principal Investigator
Name
Ashish Gautam
Degrees
Bachelor of Technology
Institution
KardioLabs LLC
Position Title
Research Scientist
Email
About this CDAS Project
Study
NLST (Learn more about this study)
Project ID
NLST-774
Initial CDAS Request Approval
Mar 30, 2021
Title
Identification and Quantification of Cardiac Calcium and cardiovascular Risk Stratification
Summary
Cardiovascular disease (CVD) is the leading cause of death and 42% of these deaths are caused by the coronary artery disease (CAD). The degree and amount of coronary artery calcification (CAC) is the strong predictor of cardiovascular events and mortality. Routinely, CAC is detected and quantified as Agatston score by the human operator by manually identifying the CAC lesions and utilizing a commercially available software. This could be a very tedious and time-consuming operator dependent process and potential of error. CAC is seen commonly in patients with risk factors undergoing chest CT. We have developed a fully automated, AI powered method using spatial features and CAC segmentation to rapidly calculate Agatston score from ECG gated non contrast Cardiac CT (Cardiac CT). We Propose to compare the efficacy of our solution in detecting and quantification of cardiac calcium in a large scale NLST cohort of Non-ECG Synchronized Chest CT. We also intend to compare the efficacy of chest CT with Non-Contrast ECG gated Cardiac CT regarding coronary calcium detection and CVD risk prediction. This will help in better treatment options in this high-risk group and better resource utilization.
Aims

Application of our AI solution in detection of coronary calcium
Quantification of Coronary Calcium
Risk Stratification Algorithm
Comparing the Efficacy of Non-ECG Synchronized Chest CT from NLST study with Non-Contrast ECG gated Cardiac CT in CVD risk prediction

Collaborators

Dr. Sudhir Rathore, Department of Cardiology, Frimley Health NHS Foundation Trust, Camberley, Surrey, UK.
Dr Sri Iyengar Department of Radiology, Frimley Health NHS Foundation Trust, Camberley, Surrey, UK.
Dr. M. Bagharatta, Department of Radiodiagnosis, SMS Medical college and Hospital, Jaipur, India
Dr. Rengarajan Rajgopal., Department of Radiodiagnosis, SMS Medical college and Hospital, Jaipur, India
Dr. Dharmendra Jain, Department of Cardiology, Banaras Hindu University, Varanasi, India.
Prashant Raghav, University of Waterloo, Waterloo, Canada.
Ashish Gautam, Kardio Labs LLC, Delhi, India.
Samir Rathore, Kardio Labs LLC, Jacksonville, USA

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